A Conducting Polymer/Protein Composite with Bactericidal and Electroactive Properties

Teixeira-Dias, Bruno; Valle, Luís J. del; Aradilla, David; Estrany, Francesc; Alemán, Carlos

doi:10.1002/mame.201100172

Cited by 18 publications

(26 citation statements)

References 61 publications

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“…[7][8][9][10] Recently, some potential biotechnological applications of this CP have also been proposed (e.g. as a biosensor for the detection of specific nucleotide sequences, 11 neurotransmitters 12 and amino acids, 13 a biocondenser with bactericide properties, 14,15 a bioactive substrate for cell adhesion and proliferation 16,17 ).…”

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confidence: 99%

A rational design for the selective detection of dopamine using conducting polymers

Fabregat

Casanovas

Redondo

et al. 2014

Phys. Chem. Chem. Phys.

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Poly(N-methylpyrrole) (PNMPy), poly(N-cyanoethylpyrrole) (PNCPy) and poly(3,4-ethylenedioxythiophene) (PEDOT) films have been prepared using both single and two polymerization steps for the selective determination of low concentrations of dopamine, ascorbic acid and uric acid in tertiary mixtures.Analysis of the sensitivity and resolution parameters derived from the electrochemical response of such films indicates that PEDOT is the most appropriate for the unambiguous detection of the three species.Indeed, the performance of PEDOT is practically independent of the presence of both gold nanoparticles at the surface of the film and interphases inside the film, even though these two factors are known to improve the electroactivity of conducting polymers. Quantum mechanical calculations on model complexes have been used to examine the intermolecular interaction involved in complexes formed by PEDOT chains and oxidized dopamine, ascorbic acid and uric acid. Results show that such complexes are mainly stabilized by C-HÁ Á ÁO interactions rather than by conventional hydrogen bonds.In order to improve the sensitivity of PEDOT through the formation of specific hydrogen bonds, a derivative bearing a hydroxymethyl group attached to the dioxane ring of each repeat unit has been designed. Poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PHMeDOT) has been prepared and characterized by FTIR, UV-vis spectroscopy, cyclic voltammetry, scanning electron microscopy and atomic force microscopy. Finally, the performance of PHMeDOT and PEDOT for the selective detection of the species mentioned above has been compared.

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confidence: 99%

A rational design for the selective detection of dopamine using conducting polymers

Fabregat

Casanovas

Redondo

et al. 2014

Phys. Chem. Chem. Phys.

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“…Thus, lysozyme (an enzyme that produces damage on bacterial cell walls) was assayed to protect PEDOT films from infection of bacterial micro-organisms [133]. Two different strategies were evaluated: (a) Adsorption of lysozyme on the surface of PEDOT substrates and (b) In situ anodic polymerization considering a solution with both 3,4-ethylenedioxythiophene monomer and lysozime.…”

Section: Applications Of Biodegradable Constructs Based On Films and mentioning

confidence: 99%

Nanomembranes and Nanofibers from Biodegradable Conducting Polymers

et al. 2013

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Abstract:This review provides a current status report of the field concerning preparation of fibrous mats based on biodegradable (e.g., aliphatic polyesters such as polylactide or polycaprolactone) and conducting polymers (e.g., polyaniline, polypirrole or polythiophenes). These materials have potential biomedical applications (e.g., tissue engineering or drug delivery systems) and can be combined to get free-standing nanomembranes and nanofibers that retain the better properties of their corresponding individual components. Systems based on biodegradable and conducting polymers constitute nowadays one of the most promising solutions to develop advanced materials enable to cover aspects like local stimulation of desired tissue, time controlled drug release and stimulation of either the proliferation or differentiation of various cell types. The first sections of the review are focused on a general overview of conducting and biodegradable polymers most usually employed and the explanation of the most suitable techniques for preparing nanofibers and nanomembranes (i.e., electrospinning and spin coating). Following sections are organized according to the base conducting polymer (e.g., Sections 4-6 describe hybrid systems having aniline, pyrrole and thiophene units, respectively). Each one of these sections includes specific subsections dealing with applications in a nanofiber or nanomembrane form. Finally, miscellaneous systems and concluding remarks are given in the two last sections. OPEN ACCESSPolymers 2013, 5 1116

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“…[143] There are also applications involving conjugated polymers, to combine surface effects with an applied electric potential. [144] All in all, it has proved extremely difficult to completely avoid bacterial adhesion, one reason being the very rapid adjustments made by bacteria in order to survive.…”

Section: Biofilm Formationmentioning

confidence: 99%

Electronic Control of Cell Cultures Using Conjugated Polymer Surfaces

Persson¹

2014

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In the field of bioelectronics various electronic materials and devices are used in combination with biological systems in order to create novel applications within cell biology and medicine. A famous example of a successful bioelectronics application is the pacemaker. Metals are the most common electrical conductors, whereas polymers are generally considered being insulators. However, in the late 1970s it was shown that a special class of polymers with conjugated double bonds, could in fact, after some chemical modifications, conduct electricity. This was the start of the research field known as conducting polymers, and then later on organic electronics, a research area that has grown rapidly during the last decades. Conjugated polymers are also suitable to interact and interface with cells and tissues, as they are generally soft, flexible and biocompatible. In addition, their chemical properties can be tailor-made through synthesis to fit biological requirements and functions. During the last years applications using organic bioelectronics have become numerous. This thesis describes applications based on different conjugated polymers aiming to stimulate and control cell cultures. When culturing cells it is of interest to be able to control events such as adhesion, spreading, proliferation, differentiation and detachment. First, the impact of different polymer compositions and redox states on the adhesion of bacteria and subsequent biofilm formation was investigated. Similar polymer electrodes were also used to steer differentiation of neural stem cells, through changes in the surface exposure of a relevant biomolecule. Controlled delivery of molecules was achieved by coating nanoporous membranes with polymers that swell and contract when changing the redox state. Finally, electronic control over cell detachment using a water-soluble polymer was achieved. When applying a positive potential to this polymer, it swells, cracks and finally detaches, taking the cells that was cultured on top along with it. Together, the work and results presented in this thesis demonstrate a versatile conjugated polymer technology to achieve electronic control of the different growth stages of cell cultures as well as cellular functions. POPULÄRVETENSKAPLIG SAMMANFATTNINGOlika plaster finns numera överallt omkring oss och utgör ett av de absolut vanligaste materialen i vår vardag. Även elektronik har blivit en naturlig del av vår tillvaro och finns i en mängd olika produkter. Inom medicinsk teknik kommer allt fler applikationer som innefattar elektronik, ett exempel är pacemakern. Arbetet som ligger till grund för denna avhandling strävar efter att kombinera plaster och elektronik för tillämpningar inom medicin och cellbiologi.Plaster består till största delen av polymerer samt olika tillsatser för att få ett material med önskade egenskaper. Polymerer är i sin tur uppbyggda av långa kedjor av identiska molekylära byggstenar, så kallade monomerer. Monomerens kemi och struktur bestämmer även egenskaperna hos polymeren. Med hjä...

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A Conducting Polymer/Protein Composite with Bactericidal and Electroactive Properties

Cited by 18 publications

References 61 publications

A rational design for the selective detection of dopamine using conducting polymers

A rational design for the selective detection of dopamine using conducting polymers

Nanomembranes and Nanofibers from Biodegradable Conducting Polymers

Electronic Control of Cell Cultures Using Conjugated Polymer Surfaces

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