A concise review on cancer treatment methods and delivery systems

Bidram, Elham; Esmaeili, Yasaman; Ranji‐Burachaloo, Hadi; Al-Zaubai, Nuha; Zarrabi, Ali; Stewart, Alastair G.; Dunstan, Dave E.

doi:10.1016/j.jddst.2019.101350

Cited by 71 publications

(56 citation statements)

References 554 publications

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“…Chemotherapy is generally given as adjuvant and neoadjuvant therapies, depending upon the type and stage of cancer. These chemotherapeutic approaches are often associated with toxicities including long-term cardiotoxicity, neurotoxicity, neuropathy, bone marrow suppression, chronic liver damage, gastrointestinal lesions, infertility and many others [ 2 ]. Moreover, 90% of cancer deaths are due to the development of resistance as the treatment proceeds [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Sharma

Singhal²,

Kumari

et al. 2020

Biomolecules

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This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol malate co-dodecanedioate (PGMD) nanoparticles. Diosgenin loaded PGMD nanoparticles (variants 7:3 and 6:4) were synthesized by the nanoprecipitation method. The synthesis of PGMD nanoparticles was systematically optimized employing the Box-Behnken design and taking into account the influence of various independent variables such as concentrations of each PGMD, diosgenin and PF-68 on the responses such as size and PDI of the particles. Mathematical modeling was done using the Quadratic second order modeling method and response surface analysis was undertaken to elucidate the factor-response relationship. The obtained size of PGMD 7:3 and PGMD 6:4 nanoparticles were 133.6 nm and 121.4 nm, respectively, as measured through dynamic light scattering (DLS). The entrapment efficiency was in the range of 77–83%. The in vitro drug release studies showed diffusion and dissolution controlled drug release pattern following Korsmeyer–Peppas kinetic model. Furthermore, in vitro morphological and cytotoxic studies were performed to evaluate the toxicity of synthesized drug loaded nanoparticles in model cell lines. The IC50 after 48 h was observed to be 27.14 µM, 15.15 µM and 13.91 µM for free diosgenin, PGMD 7:3 and PGMD 6:4 nanoparticles, respectively, when administered in A549 lung carcinoma cell lines.

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Section: Introductionmentioning

confidence: 99%

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Sharma

Singhal²,

Kumari

et al. 2020

Biomolecules

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“…Some valuable studies deal with exploring the optimum methods of drug encapsulation and the kinetics of drug/proteins load and release. Furthermore, the capability of niosomes in enhancing the bioavailability and efficacy of drugs attracts the researchers’ attention to apply niosomal drug delivery systems in treatment of severe inflammations and diseases such as different types of cancers [ 15 , 16 ]. For instance, recently, Hadjizadeh et al developed BSA-loaded niosomes, and showed the ability of this system to release its cargo slowly.…”

Section: Niosomes As New Drug Delivery Systemsmentioning

confidence: 99%

Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects

et al. 2020

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The eye is a complex organ consisting of several protective barriers and particular defense mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual impairments it is essential to provide necessary drugs through the appropriate delivery routes and vehicles. The topical route of administration, as the most commonly used approach, maybe inefficient due to low drug bioavailability. New generation safe, effective, and targeted drug delivery systems based on nanocarriers have the capability to circumvent limitations associated with the complex anatomy of the eye. Nanotechnology, through various nanoparticles like niosomes, liposomes, micelles, dendrimers, and different polymeric vesicles play an active role in ophthalmology and ocular drug delivery systems. Niosomes, which are nano-vesicles composed of non-ionic surfactants, are emerging nanocarriers in drug delivery applications due to their solution/storage stability and cost-effectiveness. Additionally, they are biocompatible, biodegradable, flexible in structure, and suitable for loading both hydrophobic and hydrophilic drugs. These characteristics make niosomes promising nanocarriers in the treatment of ocular diseases. Hereby, we review niosome based drug delivery approaches in ophthalmology starting with different preparation methods of niosomes, drug loading/release mechanisms, characterization techniques of niosome nanocarriers and eventually successful applications in the treatment of ocular disorders.

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“…Cancer is a complex disease that is a major cause of death worldwide [77], with several treatments but no cure [78]. In the light of the aggressive and not always effective treatments in current medicine, the demand for safer and better anticancer compounds have turned the search to natural products as another therapeutic approach to cancer [79].…”

Section: Antitumormentioning

confidence: 99%

Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

2020

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A current research topic of great interest is the study of the therapeutic properties of plants and of their bioactive secondary metabolites. Plants have been used to treat all types of health problems from allergies to cancer, in addition to their use in the perfumery industry and as food. Hedychium species are among those plants used in folk medicine in several countries and several works have been reported to verify if and how effectively these plants exert the effects reported in folk medicine, studying their essential oils, extracts and pure secondary metabolites. Hedychium coronarium and Hedychium spicatum are the most studied species. Interesting compounds have been identified like coronarin D, which possesses antibacterial, antifungal and antitumor activities, as well as isocoronarin D, linalool and villosin that exhibit better cytotoxicity towards tumor cell lines than the reference compounds used, with villosin not affecting the non-tumor cell line. Linalool and α-pinene are the most active compounds found in Hedychium essential oils, while β-pinene is identified as the most widespread compound, being reported in 12 different Hedychium species. Since only some Hedychium species have been investigated, this review hopes to shed some light on the uncharted territory that is the Hedychium genus.

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A concise review on cancer treatment methods and delivery systems

Cited by 71 publications

References 554 publications

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects

Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

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