Driven by China’s strategy of strength manufacturing country, the production mode of Chinese enterprises will change from traditional mechanical and electrical mode to digitizing, networking and intelligent production mode. Therefore, the intelligent manufacturing engineering major grows as a new major under that background. It has become the key to the construction of this major how to build a practical teaching system suitable for the intelligent manufacturing engineering major. Through cooperation with companies such as Huazhong CNC and Gaode Information, the application-oriented universities such as Wenhua college and Ezhou Vocational University have established a practical teaching system: Centered around intelligent manufacturing production lines, taking equipment of production line as the main line, focus on semi physical simulation platforms and digital twin virtual simulation platforms, taking vocational technical level certificates as the guide, taking digital design and programming as the foundation, and strengthened network data collection and communication control. Under the guidance of the practical teaching system, an intelligent manufacturing practical teaching platforms have been built. Which will be laid a solid practical teaching foundation for the construction of intelligent manufacturing engineering majors.