The ongoing COVID-19 pandemic is caused by SARS-CoV-2, a novel coronavirus that most likely originated near Wuhan, China, from an animal host (Li et al., 2020). The virus has infected over three million people and caused nearly a quarter-million deaths worldwide (as of 1 May 2020), while also leading to severe societal disruption, including the widespread transition of colleges and universities to online learning. Concomitant with the pandemic has been an increase in public discourse and speculation about the evolution and origin of the virus, despite numerous studies examining its evolution and zoonotic origin (e.g., Lam et al., 2020; Li et al., 2020). Given this widespread discourse about the evolution of SARS-CoV-2 and the immediate relevance of this topic amid the ongoing pandemic, I decided to modify my senior biology capstone course already underway in the spring semester of 2020 to incorporate a module on SARS-CoV-2 evolution. Here, I describe how I pivoted this course using primary literature following the CREATE (consider, read, elucidate, and think of the next experiment) model, discuss the challenges and lessons learned from conducting such a class with online instruction, and provide advice for faculty looking to incorporate this module in future classes.