A computerized automatic apparatusfor determination of mercuryin biological samples

Einarsson, Östen; Lindstedt, Gösta; Bergström, Torgil

doi:10.1155/s1463924684000158

Cited by 46 publications

(10 citation statements)

References 6 publications

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“…Mercury in whole blood, plasma, and urine was analysed by cold vapour atomic absorption spectrophotometry. '3 14 3-4% were obtained in 1 0-ml Vacutainer gel-barrier cross reactivity with 5a-dihydrotestosterone). tubes (SST A 3200, Becton-Dickinson), with Serum free testosterone was assayed by a nonthe subject in a sitting position, on the same extraction ligand-analogue technique (Coatoccasion as the blood sample for Hg estima-A-Count Free Testosterone, Diagnostic tion.…”

Section: Exposure Assessmentmentioning

confidence: 98%

Endocrine function in mercury exposed chloralkali workers.

et al. 1994

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Objective-The aim was to study whether functional impairment of the pituitary, thyroid, testes, and adrenal glands of humans occupationally exposed to mercury (Hg) vapour can be shown as a result of accumulation of Hg in these glands. Methods-Basal concentrations of thyrotrophin (TSH), prolactin, free thyroxine (free T4), free 3,5,3'-triiodothyronine (free T3), antibodies against thyroperoxidase, and testosterone in serum, as well as cortisol in morning urine were measured in 41 chloralkali workers exposed ( or on serum free thyroid hormone or testosterone concentrations.57 In one of the studies,5 however, there was a positive correlation between urinary Hg excretion and basal prolactin concentrations.Animal studies have shown that treatment with inorganic Hg inhibited enzymes involved in the biosynthesis of iodothyronines, resulting in decreased concentrations of serum thyroxine (T4). Mercurials may also affect the deiodination of T4 to 3,5,3'-triiodothyronine (T3).8 9 In animals, changes in morphology and function of the adrenals and testes have also been reported.'0-0' Subjects and methods We examined, simultaneously in age matched pairs, 41 male chloralkali workers exposed to mercury vapour and 41 occupationally unexposed deferents from the same company. Table 1 shows their ages and duration of Hg exposure. Typical air-Hg concentrations at ordinary work were 20-50 ug/m3, but during maintenance the values were higher.'2 There were 18 smokers in the exposed group and 20 among the referents. Alcohol consumption was moderate, and there was no difference between exposed subjects and referents. EXPOSURE ASSESSMENTVenous blood samples were obtained between 9 00 am and 2 00 pm in metal free heparinised Venoject tubes. Morning urine samples were collected in Hg free polyethylene bottles. After separation of plasma, the samples were stored at -25°C. Mercury in whole blood, plasma, and urine was analysed by cold vapour atomic absorption spectrophotometry.'3 14 Lack of precision (coefficient of variation (CV)

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Section: Exposure Assessmentmentioning

confidence: 98%

Endocrine function in mercury exposed chloralkali workers.

et al. 1994

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“…Mercury was determined in wet-digested samples using an automized cold vapor atomic absorption technique (24). For the determination of total mercury, blood (0.5 g) was digested with concentrated nitric (0.5 ml) and perchloric (2.5 ml) acids at 65°C overnight (25).…”

Section: Mercury In Bloodmentioning

confidence: 99%

Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen

Svensson¹,

Nilsson²,

Jonsson³

et al. 1995

Scand J Work Environ Health

136

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“…Exposure can be monitored by measuring mercury in the breathing zone of exposed workers using either active or passive personal sampling techniques (15) (17). To correct for urinary flow rate, mercury concentrations in urine were adjusted for creatinine, which was analyzed with a modified kinetic Jaffd method (18).…”

mentioning

confidence: 99%

“…Nearly all workers participated in the biomonitoring program, but approximately one-half of the workforce was monitored by personal sampling. We analyzed air samples using standard methods (16); determinations of mercury in biological samples were made using cold vapor atomic absorption spectrophotometry (17). To correct for urinary flow rate, mercury concentrations in urine were adjusted for creatinine, which was analyzed with a modified kinetic Jaffd method (18 (20).…”

mentioning

confidence: 99%

Variability in Airborne and Biological Measures of Exposure to Mercury in the Chloralkali Industry: Implications for Epidemiologic Studies

Symanski¹,

Sällsten²,

Barregård³

2000

Environmental Health Perspectives

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Exposure assessment is a critical component of epidemiologic studies, and more sophisticated approaches require that variation in exposure be considered. We examined the intr-and interindividual sources ofvariation in exposure to mercury vapor as measured in air, blood, and urine among four groups of workers during 1990-1997 at a Swedish chloralii plant. Consistent with the underlying kdnetics of mercury in the body, the variability of biological measures was dampened considerably relative to Intraindividual variability in exposure can induce error in exposure assessment and thereby can adversely affect epidemiologic studies by reducing the power to detect associations and by diminishing measures of effect (8-13). To assess the magnitude of the error in an exposure measure, the well-established techniques of analysis of variance can be applied (when repeated measurements on study subjects are available) to estimate the magnitude of the intra-and interindividual sources of variation. Information contained in the estimated variance components can then be used to assess the bias in measures of effect and to optimize study design in terms of the number of workers to be studied and the number of samples to collect.In the chloralkali industry, exposure to mercury vapor (Hg0) can occur during the production of chlorine through the electrolysis of a brine solution in mercury cells (14). Exposure can be monitored by measuring mercury in the breathing zone of exposed workers using either active or passive personal sampling techniques (15) (17). To correct for urinary flow rate, mercury concentrations in urine were adjusted for creatinine, which was analyzed with a modified kinetic Jaffd method (18). There

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A computerized automatic apparatusfor determination of mercuryin biological samples

Cited by 46 publications

References 6 publications

Endocrine function in mercury exposed chloralkali workers.

Endocrine function in mercury exposed chloralkali workers.

Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen

Variability in Airborne and Biological Measures of Exposure to Mercury in the Chloralkali Industry: Implications for Epidemiologic Studies

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