A computer simulation of short-term adaptations of cardiovascular hemodynamics in microgravity

Gerber, Benjamin; Singh, John-Luke; Zhang, Yan; Liou, William W.

doi:10.1016/j.compbiomed.2018.09.014

Cited by 17 publications

(16 citation statements)

References 33 publications

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“…Given the above difficulties, the computational approach is a recent and promising tool to study the human body's response to microgravity conditions [14][15][16][17][18] , as it can be used to investigate variables and processes which are hard to measure, as well as predict different scenarios and optimal countermeasures. In particular, reduced order modeling seems to be the most appropriate strategy, as it is a reasonable balance between the suitable level of local detail and the overall response (see, among the most recent [19][20][21][22][23] ).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling

2020

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Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology, and push scientific boundaries further. A key area of importance is cardiovascular deconditioning, that is, the collection of hemodynamic changes—from blood volume shift and reduction to altered cardiac function—induced by sustained presence in microgravity. A thorough grasp of the 0G adjustment point per se is important from a physiological viewpoint and fundamental for astronauts’ safety and physical capability on long spaceflights. However, hemodynamic details of cardiovascular deconditioning are incomplete, inconsistent, and poorly measured to date; thus a computational approach can be quite valuable. We present a validated 1D–0D multiscale model to study the cardiovascular response to long-term 0G spaceflight in comparison to the 1G supine reference condition. Cardiac work, oxygen consumption, and contractility indexes, as well as central mean and pulse pressures were reduced, augmenting the cardiac deconditioning scenario. Exercise tolerance of a spaceflight traveler was found to be comparable to an untrained person with a sedentary lifestyle. At the capillary–venous level significant waveform alterations were observed which can modify the regular perfusion and average nutrient supply at the cellular level. The present study suggests special attention should be paid to future long spaceflights which demand prompt physical capacity at the time of restoration of partial gravity (e.g., Moon/Mars landing). Since spaceflight deconditioning has features similar to accelerated aging understanding deconditioning mechanisms in microgravity are also relevant to the understanding of aging physiology on the Earth.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling

2020

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“…During space travelling, astronauts may come across extreme environmental conditions such as microgravity, noise, radiation, confinement, and circadian rhythm disorder [1][2][3]. Previous studies focused mainly on physiological and psychological changes such as bone mineral loss [4][5][6], cardiovascular disruption [7][8][9], immune system malfunctioning [10][11][12], cognitive dysfunction [13][14][15][16], risky decision making, bad mood status, and high depression levels [1,17,18] under the microgravity [19][20][21]. Few reports explore how the extreme complex space environment affects astronauts' physiological and psychological functions.…”

Section: Introductionmentioning

confidence: 99%

Deep Membrane Proteome Profiling of Rat Hippocampus in Simulated Complex Space Environment by SWATH

Wang

Qin²,

Hong

et al. 2021

Space Sci Technol

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Despite the development and great progress in the field of space biology, the astronauts are still facing many challenges in space. The space environment in which astronauts stay includes microgravity, noise, circadian rhythms disorder, and confinement, which has deep effect both on the physiology and psychology of astronauts. It was reported that long-term flight could cause the astronauts’ anxiety and depression. However, the underlying mechanism is not yet fully understood. Therefore, in the present study, the rat tail suspension model with noise, circadian rhythms, and confinement was employed to simulate complex space environment. We found that the rats exhibited the depressive-like behavior by the sucrose preference, forced swimming, and open-field tests. The membrane proteome of the rat hippocampus was investigated by “SWATH quantitation” technology both in control and simulated complex space environment (SCSE) groups. Out of 4520 quantified proteins, 244 differentially expressed membrane proteins were obtained between the SCSE and control rats, which were functionally enriched in a series of biological processes, such as translation, protein phosphorylation, brain development, endocytosis, nervous system development, axonogenesis, and vesicle-mediated transport. We found a reduction level of neurexin-2, the light, medium, heavy polypeptide of neurofilament, rab 18, synaptogyrin 1, and syntaxin-1A and an increase level of neuroligin-1, munc18, snapin, synaptotagmin XII, complexin-1, etc., which may play a key part in the development of depression. Furthermore, GSK-3β protein was upregulated in mass spectrometry, which was further validated by western blotting. The results of the study do the favor in designing the effective countermeasures for the astronauts in the future long-term spaceflight.

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“…The data which are gathered or extracted from spaceflight and other experiments such as parabolic flights have been documented to validate the results of simulations [19].…”

Section: Computer Simulation (Especially In Musculoskeletal Biomechanmentioning

confidence: 99%

Vitamin D in Space

Khoshvaghti¹

2019

Fads and Facts About Vitamin D

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Mankind has explored space since many years ago for distinct purposes. The space environment has its special features including microgravity (weightlessness), radiation, vacuum, and extreme temperature. It is fascinating to hear space traveling or even living on another planet, but it may cause dramatic changes in the human body. The skeleton has the primary role for the human body on the Earth and also in space. Osteoporosis is the principal feature in spaceflights occurring sooner or later. It will pose health risks. The aging of the population is the cause for osteoporosis to be more prevalent in the future. It seems that aging will happen sooner in space for human beings that are accustomed to living on the Earth. A complex of all reported changes that would occur in space, the picture of a closely resembling aged man emerges. Vitamin D can be synthesized and acts as a hormone. Its receptors are evident in more than 30 human tissues. Vitamin D has positive effects on the skeleton and other systems of the body in many regards. Multiple actions have been claimed for vitamin D (real or false), many aspects of which are not fully understood. The issue applies more about the vitamin and space, which has been tried to describe in this chapter.

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A computer simulation of short-term adaptations of cardiovascular hemodynamics in microgravity

Cited by 17 publications

References 33 publications

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling

Deep Membrane Proteome Profiling of Rat Hippocampus in Simulated Complex Space Environment by SWATH

Vitamin D in Space

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