A computer program in compiled basic for the IBM personal computer to calculate the mean platelet survival time with the multiple-hit and weighted mean methods

Preliminary validation of a new standard of efficacy for stored platelets

“…This variable would reflect both the recovery and survival of the platelets in a single measure, but this may place an inappropriate weight on the survival estimation. Because the life span of platelets is greatly reduced during thrombocytopenia 11 (presumably due to consumption in normal hemostasis), Murphy has argued that adequate recovery is probably the more important finding to demonstrate and that clinical utility of a platelet preparation could be achieved with a life span that is more reduced than the recovery 5 . Because survival appears to be better maintained (in a relative sense) than recovery after both 5 and 7 days, focusing on recovery rather than survival or area under the survival curve might be expected to provide a more sensitive means of gauging the clinical utility of a platelet system.…”

“…Recovery was calculated from the injected radioactivity, and the highest recovery noted within the first 3 hours after infusion was reported. Survival and the area under the survival curve were determined using the multiple‐hit model using a computer program 11 …”

Viability and function of 8‐day‐stored apheresis platelets

“…Several investigators involved in evaluating stored radiolabeled PLT viability are developing guidelines for methods to radiolabel PLTs, how and when each donor’s fresh PLTs should be collected and transfused, and what calculations should be used to determine posttransfusion PLT recoveries and survivals. Agreement has been reached on the method to be used for radiolabeling PLTs and on the calculations used to determine PLT recoveries and survivals 12,13 . In addition, it has been agreed that, on the day the donor’s stored PLTs are to be transfused, a blood sample will be drawn from the donor to obtain fresh PLTs for radiolabeling permitting concurrent transfusion of the fresh and stored PLTs 11…”

Post-Transfusion Red Blood Cell and Platelet Survival and Kinetics: Basic Principles and Practical Aspects

“…15 With this "elution correction," the recovery curves for platelets labeled with 111 In are coincident with those labeled with 51 Cr. 52,53 These calculations can also be performed on statistical analysis software to achieve the same results. 51 There are four methods for the calculation of platelet life span-linear, exponential, weighted mean, and γ-function (multiple hit)-each of which yields slightly different results.…”