A computational workflow for the detection of candidate diagnostic biomarkers of Kawasaki disease using time-series gene expression data

Pezoulas, Vasileios C.; Papaloukas, Costas; Veyssiere, Maëva; Goules, Andreas V.; Tzioufas, Athanasios G.; Soumelis, Vassili; Fotiadis, Dimitrios I.

doi:10.1016/j.csbj.2021.05.036

“…As expected based on past machine learning applications on gene expression data [45] , juxtaposition of the models’ performance showed relatively small differences. In brief, evaluation on the testing set placed our lite model among the top performing methods, while Xu-based classifier showed the lowest efficiency in separating IPF from control individuals.…”

Section: Discussionsupporting

confidence: 76%

An explainable machine learning-driven proposal of pulmonary fibrosis biomarkers

Fanidis¹,

Pezoulas²,

Fotiadis³

et al. 2023

Computational and Structural Biotechnology Journal

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“…32 Also, a set of five genes are candidates as biomarkers for KD diagnosing, namely, the HLA-DQB1, HLA-DRA, ZBTB48, TNFRSF13C, and CASD1. 33 Neurological involvement in Kawasaki disease Neurologic involvement in KD is reported in 1.1% to 3.7% of KD cases. 34 It ranges from common symptoms like irritability and lethargy to multi-system involvement such as seizures, myositis, sterile infectious diseases, facial palsy, hemiplegia, and coma.…”

Section: Biomarkersmentioning

confidence: 99%

Neurological involvement, immune response, and biomarkers in Kawasaki disease along with its pathogenesis, therapeutic and diagnostic updates

Amir¹,

Prajjwal

²

,

Inban³

et al. 2023

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Kawasaki disease is an acute, febrile disease that is not typically fatal if treated and affects infants and children more commonly. More than 80% of the afflicted patients are under the age of four. This disease most commonly affects coronary arteries. In a minority of cases, Aneurysms can burst or produce thrombosis, and they can cause infarction. The distinctive redness in the palms and soles of the feet might result from a delayed-type hypersensitivity reaction to a cross-reactive or recently discovered antigen (s). Autoantibodies against epithelial cells and smooth muscle cells are produced as a result of subsequent macromolecule synthesis and polyclonal white blood cell activation, which intensifies the redness. Kawasaki disease's clinical manifestations range from oral skin disease to the blistering of the mucosa, symptoms involving the hands and the feet, skin disease of the palms and soles, a desquamative rash, and cervical lymphatic tissue enlargement (so it is also referred to as tissue layer lymphatic tissue syndrome). Most untreated patients develop some vessel sequelae, from well-organized coronary inflammation to severe arterial blood vessel dilatation to giant artery aneurysms with rupture or occlusion, infarction, and thrombosis. With human gamma globulin administration, reasonable standards of medical care, and the use of analgesics, the speed of symptomatic progression and inflammatory artery changes are reduced. In this review, we have covered the immunology of Kawasaki disease, its biomarkers, and the neurological manifestations of this multisystem illness. We have also included a discussion on its pathogenesis, diagnosis, and treatment.

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“…33 Also, a set of five genes are candidates as biomarkers for KD diagnosing, namely, the HLA-DQB1, HLA-DRA, ZBTB48, TNFRSF13C, and CASD1. 34…”

Section: Biomarkersmentioning

confidence: 99%

Neurological involvement, immune response, and biomarkers in Kawasaki disease along with its pathogenesis, therapeutic and diagnostic updates

Amir¹,

Prajjwal

²

,

Inban³

et al. 2023

F1000Res

0

View full text Add to dashboard Cite

Kawasaki disease is an acute, febrile disease that is not typically fatal if treated and affects infants and children more commonly. More than 80% of the afflicted patients are under the age of four. This disease most commonly affects coronary arteries. In a minority of cases, Aneurysms can burst or produce thrombosis, and they can cause infarction. The distinctive redness in the palms and soles of the feet might result from a delayed-type hypersensitivity reaction to a cross-reactive or recently discovered antigen (s). Autoantibodies against epithelial cells and smooth muscle cells are produced as a result of subsequent macromolecule synthesis and polyclonal white blood cell activation, which intensifies the redness. Kawasaki disease's clinical manifestations range from oral skin disease to the blistering of the mucosa, symptoms involving the hands and the feet, skin disease of the palms and soles, a desquamative rash, and cervical lymphatic tissue enlargement (so it is also referred to as tissue layer lymphatic tissue syndrome). Most untreated patients develop some vessel sequelae, from well-organized coronary inflammation to severe arterial blood vessel dilatation to giant artery aneurysms with rupture or occlusion, infarction, and thrombosis. With human gamma globulin administration, reasonable standards of medical care, and the use of analgesics, the speed of symptomatic progression and inflammatory artery changes are reduced. In this review, we have covered the immunology of Kawasaki disease, its biomarkers, and the neurological manifestations of this multisystem illness. We have also included a discussion on its pathogenesis, diagnosis, and treatment.

show abstract

A computational workflow for the detection of candidate diagnostic biomarkers of Kawasaki disease using time-series gene expression data

Abstract: Graphical abstract

Cited by 9 publications

References 44 publications

An explainable machine learning-driven proposal of pulmonary fibrosis biomarkers

An explainable machine learning-driven proposal of pulmonary fibrosis biomarkers

Neurological involvement, immune response, and biomarkers in Kawasaki disease along with its pathogenesis, therapeutic and diagnostic updates

Neurological involvement, immune response, and biomarkers in Kawasaki disease along with its pathogenesis, therapeutic and diagnostic updates

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