“…Some researchers have developed computational tools that enable analysis of multiple scenarios using a set of random variables simultaneously and efficiently (Browne and Langley, 1999;Nicolella et al, 2001;Bah and Browne, 2003;Perez et al, 2006;Easley et al, 2007;Mehrez, 2007). In probabilistic studies on THR models, it has been shown that there are many important random variables, such as bone geometry, implant design geometry, cement geometry, material properties, magnitude and direction of applied loads, and bone-implant relative position that can affect performance (Browne and Langley, 1999;Nicolella et al, 2001;Bah and Browne, 2003;Perez et al, 2006;Easley et al, 2007;Mehrez, 2007;Dopico-Gonzalez et al, 2009a;Dopico-Gonzalez et al, 2009b;Halpern and Tanner, 1979;Heller et al, 2001;Herrlin et al, 1988;Laz et al, 2007a;Nicolella et al, 2006;Nishii et al, 2004;Reikeras et al, 1982;Speirs et al, 2007;Yang et al, 1984). This suggests that it is not appropriate to extrapolate the results obtained from simulation studies of one model to the whole population of femurs and implant designs.…”