A computational study of the effect of vocal-fold asymmetry on phonation

Xue, Qian; Mittal, Rajat; Zheng, Xudong; Bielamowicz, Steven

doi:10.1121/1.3458839

Cited by 38 publications

(36 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, in Steinecke and Herzel (1995), the normal fold always exhibited a smaller vibration amplitude than the soft fold. This contrasts with Xue et al (2010) in which the normal fold exhibited a greater amplitude than that of the soft fold at certain conditions.…”

Section: Introductioncontrasting

confidence: 47%

“…Similar excitation of the stiff fold to vibrate at its own natural frequency was also observed in Zhang (2010b) but not as strongly as observed in this study. Such subharmonic synchronization was also observed in the simulation of Xue et al (2010) and discussed in detail in Steinecke and Herzel (1995).…”

Section: A Experimentsmentioning

confidence: 58%

“…There have been many previous studies on vocal fold vibration in asymmetric conditions (e.g., Isshiki et al, 1977;Sercarz et al, 1992;Moore et al, 1987;Smith et al, 1992;Berke and Gerratt, 1993;Steinecke and Herzel, 1995;Xue et al, 2010). While many studies (e.g., Ishizaka and Isshiki, 1976;Isshiki et al, 1977;Sercarz et al, 1992;Steinecke and Herzel, 1995;Pickup and Thomson, 2009;Xue et al, 2010) reported that the motion of the normal fold preceded the paralyzed fold in phase, the opposite (i.e., the soft fold leads in phase) was also reported (e.g., Moore et al, 1987).…”

Section: Introductionmentioning

confidence: 92%

“…While many studies (e.g., Ishizaka and Isshiki, 1976;Isshiki et al, 1977;Sercarz et al, 1992;Steinecke and Herzel, 1995;Pickup and Thomson, 2009;Xue et al, 2010) reported that the motion of the normal fold preceded the paralyzed fold in phase, the opposite (i.e., the soft fold leads in phase) was also reported (e.g., Moore et al, 1987). Inconsistence also exists in the literature regarding the relative difference in vibration amplitude.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Asymmetric vibration in a two-layer vocal fold model with left-right stiffness asymmetry: Experiment and simulation

Zhang¹,

Luu²

2012

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Vibration characteristics of a self-oscillating two-layer vocal fold model with left-right asymmetry in body-layer stiffness were experimentally and numerically investigated. Two regimes of distinct vibratory pattern were identified as a function of left-right stiffness mismatch. In the first regime with extremely large left-right stiffness mismatch, phonation onset resulted from an eigenmode synchronization process that involved only eigenmodes of the soft fold. Vocal fold vibration in this regime was dominated by a large-amplitude vibration of the soft fold, and phonation frequency was determined by the properties of the soft fold alone. The stiff fold was only enslaved to vibrate at a much reduced amplitude. In the second regime with small left-right stiffness mismatch, eigenmodes of both folds actively participated in the eigenmode synchronization process. The two folds vibrated with comparable amplitude, but the stiff fold consistently led the soft fold in phase for all conditions. A qualitatively good agreement was obtained between experiment and simulation, although the simulations generally underestimated phonation threshold pressure and onset frequency. The clinical implications of the results of this study are also discussed.

show abstract

Section: Introductioncontrasting

confidence: 47%

Section: A Experimentsmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Asymmetric vibration in a two-layer vocal fold model with left-right stiffness asymmetry: Experiment and simulation

Zhang¹,

Luu²

2012

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

show abstract

“…The model proposed by Steinecke and Herzel (1995) has been repeatedly used to study asymmetric behavior during phonation Wurzbacher et al, 2006;Zhang et al, 2006) and whose behavior has been validated by more complex models that use Navier-Stokes flow solvers (Tao et al, 2007;Xue et al, 2010). Although alternative representations, such as the body-cover model (Story and Titze, 1995), may offer an enhanced feature set, they do not provide simple control over left-right vibratory asymmetry and have not been consistently applied to study asymmetric vocal fold vibration.…”

Section: Introductionmentioning

confidence: 99%

Investigating acoustic correlates of human vocal fold vibratory phase asymmetry through modeling and laryngeal high-speed videoendoscopy

Mehta

Zañartu

Quatieri

et al. 2011

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Vocal fold vibratory asymmetry is often associated with inefficient sound production through its impact on source spectral tilt. This association is investigated in both a computational voice production model and a group of 47 human subjects. The model provides indirect control over the degree of left-right phase asymmetry within a nonlinear source-filter framework, and high-speed videoendoscopy provides in vivo measures of vocal fold vibratory asymmetry. Source spectral tilt measures are estimated from the inverse-filtered spectrum of the simulated and recorded radiated acoustic pressure. As expected, model simulations indicate that increasing left-right phase asymmetry induces steeper spectral tilt. Subject data, however, reveal that none of the vibratory asymmetry measures correlates with spectral tilt measures. Probing further into physiological correlates of spectral tilt that might be affected by asymmetry, the glottal area waveform is parameterized to obtain measures of the open phase (open=plateau quotient) and closing phase (speed=closing quotient). Subjects' left-right phase asymmetry exhibits low, but statistically significant, correlations with speed quotient (r ¼ 0.45) and closing quotient (r ¼ À0.39). Results call for future studies into the effect of asymmetric vocal fold vibration on glottal airflow and the associated impact on voice source spectral properties and vocal efficiency.

show abstract

Recurrent laryngeal nerve transection in mice results in translational upper airway dysfunction

Haney

Hamad

Woldu

et al. 2019

J of Comparative Neurology

View full text Add to dashboard Cite

The recurrent laryngeal nerve (RLN) is responsible for normal vocal‐fold (VF) movement, and is at risk for iatrogenic injury during anterior neck surgical procedures in human patients. Injury, resulting in VF paralysis, may contribute to subsequent swallowing, voice, and respiratory dysfunction. Unfortunately, treatment for RLN injury does little to restore physiologic function of the VFs. Thus, we sought to create a mouse model with translational functional outcomes to further investigate RLN regeneration and potential therapeutic interventions. To do so, we performed ventral neck surgery in 21 C57BL/6J male mice, divided into two groups: Unilateral RLN Transection (n = 11) and Sham Injury (n = 10). Mice underwent behavioral assays to determine upper airway function at multiple time points prior to and following surgery. Transoral endoscopy, videofluoroscopy, ultrasonic vocalizations, and whole‐body plethysmography were used to assess VF motion, swallow function, vocal function, and respiratory function, respectively. Affected outcome metrics, such as VF motion correlation, intervocalization interval, and peak inspiratory flow were identified to increase the translational potential of this model. Additionally, immunohistochemistry was used to investigate neuronal cell death in the nucleus ambiguus. Results revealed that RLN transection created ipsilateral VF paralysis that did not recover by 13 weeks postsurgery. Furthermore, there was evidence of significant vocal and respiratory dysfunction in the RLN transection group, but not the sham injury group. No significant differences in swallow function or neuronal cell death were found between the two groups. In conclusion, our mouse model of RLN injury provides several novel functional outcome measures to increase the translational potential of findings in preclinical animal studies. We will use this model and behavioral assays to assess various treatment options in future studies.

show abstract

A computational study of the effect of vocal-fold asymmetry on phonation

Cited by 38 publications

References 33 publications

Asymmetric vibration in a two-layer vocal fold model with left-right stiffness asymmetry: Experiment and simulation

Asymmetric vibration in a two-layer vocal fold model with left-right stiffness asymmetry: Experiment and simulation

Investigating acoustic correlates of human vocal fold vibratory phase asymmetry through modeling and laryngeal high-speed videoendoscopy

Recurrent laryngeal nerve transection in mice results in translational upper airway dysfunction

Contact Info

Product

Resources

About