A computational model to uncover the biophysical underpinnings of neural firing heterogeneity in dissociated hippocampal cultures
Vaibhav Dhyani,
Kevin George,
Suman Gare
et al.
Abstract:Calcium (Ca2+) imaging reveals a variety of correlated firing in cultures of dissociated hippocampal neurons, pinpointing the non‐synaptic paracrine release of glutamate as a possible mediator for such firing patterns, although the biophysical underpinnings remain unknown. An intriguing possibility is that extracellular glutamate could bind metabotropic receptors linked with inositol trisphosphate (IP3) mediated release of Ca2+ from the endoplasmic reticulum of individual neurons, thereby modulating neural act… Show more
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