1999
DOI: 10.1109/10.759051
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A computational model of electrical stimulation of the retinal ganglion cell

Abstract: Localized retinal electrical stimulation in blind volunteers results in discrete round visual percepts corresponding to the location of the stimulating electrode. The success of such an approach to provide useful vision depends on elucidating the neuronal target of surface electrical stimulation. To determine if electrodes preferentially stimulate ganglion cells directly below them or passing fibers from distant ganglion cells, we developed a compartmental model for electric field stimulation of the retinal ga… Show more

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Cited by 175 publications
(134 citation statements)
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“…Several experimental measurements of the strength-duration relationship have been reported (Jankowska and Roberts 1972;Jensen et al 2005;Sekirnjak et al 2006;Yoemans et al 1988) and some computations have been performed (Greenberg et al 1999;Richardson et al 2000). However, all such calculations and many of the measurements have focused on simple monophasic or biphasic stimuli not much shorter than chronaxy.…”
Section: Introductionmentioning
confidence: 99%
“…Several experimental measurements of the strength-duration relationship have been reported (Jankowska and Roberts 1972;Jensen et al 2005;Sekirnjak et al 2006;Yoemans et al 1988) and some computations have been performed (Greenberg et al 1999;Richardson et al 2000). However, all such calculations and many of the measurements have focused on simple monophasic or biphasic stimuli not much shorter than chronaxy.…”
Section: Introductionmentioning
confidence: 99%
“…In all of these applications, the characteristics of the stimulation waveform (principally the amplitude, polarity, and pulse width) play an important role in the design of a particular prosthetic device, making it critical to understand the relationship between stimulation threshold and pulse duration. Electrical stimulation of the retinal ganglion cells (RGC), used in epiretinal prostheses, was extensively studied by several research groups (Fried et al 2006;Jensen et al 2003Jensen et al , 2005Sekirnjak et al 2006Sekirnjak et al , 2008Stett et al 2000Stett et al , 2007Tsai et al 2009), and the strengthduration relationship has been experimentally measured (Jensen et al 2003(Jensen et al , 2005Sekirnjak et al 2006;Tsai et al 2009) and modeled computationally (Boinagrov et al 2010;Greenberg et al 1999). The strength-duration relationship defines for a given pulse duration the minimum stimulus strength, or stimulation threshold, above which an action potential (AP) is generated.…”
mentioning
confidence: 99%
“…Choosing that pulse duration, the amount of current needed to generate the response of a cell is much lower than that required to generate an axonal response. Greenberg et al, supported these observations by reporting that axonal threshold was 20% higher than that of the retinal ganglion cell [80]. Experimental findings by Jepson [63] exhibited single spike responses with sub-millisecond latency which is a characteristic of direct ganglion cell activation.…”
Section: Limitationsmentioning
confidence: 89%