A computational model for single cell Lamin‐A structural organization after microfluidic compression
Maria Isabella Maremonti,
Filippo Causa
Abstract:In recent years, nuclear mechanobiology gained a lot of attention for the study of cell responses to external cues like adhesive forces, applied compression, and/or shear‐stresses. In details, the Lamin‐A protein—as major constituent of the cell nucleus structure—plays a crucial role in the overall nucleus mechanobiological response. However, modeling and analysis of Lamin‐A protein organization upon rapid compression conditions in microfluidics are still difficult to be performed. Here, we introduce the possi… Show more
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