A computational framework for the multiphysics simulation of microbubble-mediated sonothrombolysis using a forward-viewing intravascular transducer

Tan, Zhi Q.; Ooi, Ean Hin; Chiew, Yeong Shiong; Foo, Ji Jinn; Ng, E. Y. K.; Ooi, Ean Tat

doi:10.1016/j.ultras.2023.106961

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…A lower thrombolytic dose in turn reduces the risk of hemorrhage and other complications. Acoustic radiation force also creates motion in the blood surrounding the thrombus, a process called acoustic streaming, which increases clot permeation and facilitates thrombus penetration by the thrombolytic drug [33]. Additional fibrin-binding sites are also exposed to plasmin at the area of thrombus via acoustic streaming [34].…”

Section: Mechanical Effectsmentioning

confidence: 99%

“…Stable cavitation refers to milder bubble oscillation, which also generates mechanical damage as the bubbles within the thrombus expand and contract during ultrasound. With the addition of a microbubble contrast agent, the likelihood of cavitation increases [33,35]. The mechanical index, which will be discussed in greater detail later, is a marker for an ultrasound beam's ability to cause cavitation-related effects, which essentially reflects tissue mechanical damage [36].…”

Section: Acoustic Cavitationmentioning

confidence: 99%

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Sonothrombolysis: State-of-the-Art and Potential Applications in Children

Ward,

Martinez-Correa,

Tierradentro-García

et al. 2023

Children

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In recent years, advances in ultrasound therapeutics have been implemented into treatment algorithms for the adult population; however, the use of therapeutic ultrasound in the pediatric population still needs to be further elucidated. In order to better characterize the utilization and practicality of sonothrombolysis in the juvenile population, the authors conducted a literature review of current pediatric research in therapeutic ultrasound. The PubMed database was used to search for all clinical and preclinical studies detailing the use and applications of sonothrombolysis, with a focus on the pediatric population. As illustrated by various review articles, case studies, and original research, sonothrombolysis demonstrates efficacy and safety in clot dissolution in vitro and in animal studies, particularly when combined with microbubbles, with potential applications in conditions such as deep venous thrombosis, peripheral vascular disease, ischemic stroke, myocardial infarction, and pulmonary embolism. Although there is limited literature on the use of therapeutic ultrasound in children, mainly due to the lower prevalence of thrombotic events, sonothrombolysis shows potential as a noninvasive thrombolytic treatment. However, more pediatric sonothrombolysis research needs to be conducted to quantify the safety and ethical considerations specific to this vulnerable population.

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Section: Mechanical Effectsmentioning

confidence: 99%