A Computational Framework for Patient‐Specific Analysis of Articular Cartilage Incorporating Structural Information from DT‐MRI

Abstract

MSC (2000) 74L15, 74E10, 92C55, 92C10Accurate techniques for simulating soft biological tissue deformation are an increasingly valuable tool in many areas of biomechanical analysis and medical image computing. To model the morphology and the material response of human articular cartilage a phenomenological and patient-specific simulation approach incorporating the collagen fibre fabric is proposed. We then demonstrate a unique combination of ultra-high field Diffusion Tensor Magnetic Resonance Imaging (17.6T DT-MRI) and a novel numerical approach incorporating the empirical data to predict the collagen fibre fabric deformation for an indentation experiment.