A computational fluid dynamics simulation study of coronary blood flow affected by graft placement

Lassaline, J. V.; Moon, Byung C.

doi:10.1093/icvts/ivu034

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…Non-Newtonian models have been employed with increasing frequency for flow simulations of various vascular components, such as the aorta [Karimi et al (2014); Morbiducci et al (2013); Liu et al (2011)], the cerebral [Bernabeu et al (2013);Campo-Deaño et al (2015)], and the coronary arteries [Johnston et al (2006); Lassaline et al (2014); Chaichana et al (2012); Soulis et al (2008)]. In all of these cases, generalized Newtonian expressions are adopted which can better capture the complex behavior of the fluid under steady state conditions.…”

Section: Introductionmentioning

confidence: 99%

“…In all of these cases, generalized Newtonian expressions are adopted which can better capture the complex behavior of the fluid under steady state conditions. However, while there is strong evidence to support that the Casson model is the most suitable among constitutive equations for the description of blood flow faithfully, reproducing both its yield stress and shear thinning viscoplastic characteristics [Apostolidis and Beris (2014)], researchers often employ different models such as the Carreau-Yasuda [Lassaline et al (2014); Bernabeu et al (2013)] or a general power law [Chaichana et al (2012); Johnston et al (2006)]. The differences in the predictions of various rheological models are presented in a comparative study of Karimi et al (2014).…”

Section: Introductionmentioning

confidence: 99%

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Non-Newtonian effects in simulations of coronary arterial blood flow

Apostolidis¹,

Moyer²,

Beris³

2016

Journal of Non-Newtonian Fluid Mechanics

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We present a careful evaluation of non-Newtonian blood rheology effects in arterial flow simulations. We achieve that by comparing the converged solutions obtained a) from a Casson viscoplastic modeling of blood rheology using a recently developed parametrization [Apostolidis and Beris, J. Rheol., 58: 607-633 (2014)], and b) from a Newtonian model. We emphasize on the proper implementation of outlet boundary conditions (OBCs) in a way that ensures consistency with the pressure/flow predictions of the downstream network, which is modeled approximately using a 1D model [Johnson et al., Comp. Chem. Eng., 35: 1304-1316 (2011)]. We further improve and validate the iterative scheme proposed by [Johnson et al., Int. J. Num. Meth. Fluids, 66: 1383-1408 (2011)] for the implementation of the OBCs, by employing it in conjunction with a) Casson-derived simulation data, b) a more accurate geometrical model and c) an accelerated convergence iterative scheme through application of Shanks transformation. Finally, we performed a rigorous analysis to ensure appropriately converged solutions. Our investigation shows significant differences (up to 50%) between the simulation output of Newtonian and non-Newtonian models. The differences are attributed to the coupling that exists between low and high shear rate areas in the flow. They show the significance of non-Newtonian blood rheology and motivate further work towards an even more accurate modeling of the thixoropic and three-dimensional characteristics of the blood flow rheology that go beyond the Casson model utilized in the present work.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-Newtonian effects in simulations of coronary arterial blood flow

Apostolidis¹,

Moyer²,

Beris³

2016

Journal of Non-Newtonian Fluid Mechanics

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“…The flow distributions at natural arteries and grafts are set according to previous study. 9 The data of entrances flows are recorded by the paperless recorder every 0.05 s. The data of average inlet flow are obtained with MATLAB to calculate the average value of 100 periods (Figure 2…”

Section: Experimental Systemmentioning

confidence: 99%

“…[3][4][5] Nevertheless, CABG may be at the risk of failure after operation a few years due to intimal hyperplasia (IH) related to abnormal blood flow. [6][7][8] Flow fields, which play a significant role on influencing the genesis and development of IH, are profoundly affected by the anastomotic angle (a), 9,10 the ratios of graft-host diameter (F), 11 the degree of artery stenosis, 12,13 and so on. Numerous studies have been accomplished on flow fields within anastomosis region.…”

Section: Introductionmentioning

confidence: 99%

The effect of anastomotic angle and diameter ratio on flow field in the distal end-to-side anastomosis

Liu

Yang

Nan

et al. 2019

Proc Inst Mech Eng H

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Flow fields in the distal end-to-side anastomosis of coronary artery bypass graft are associated with intimal hyperplasia and bypass failure. This work aims to demonstrate the effect of anastomotic angle and diameter ratio on flow field of coronary artery bypass graft. The flow fields inside polydimethylsiloxane models of coronary artery bypass graft with various anastomotic angles ( α = 30°, 45°, 60° and 75°) and different diameter ratios ( Φ = 0.78 and 1.11) are investigated using particle image velocimetry and computational fluid dynamics method under pulsatile flow condition. The results show that the anastomotic angle is positively correlated with the number and area of the recirculation zone, and the flow field disturbance at the anastomosis will develop in the same direction. Compared with that of Φ = 0.78, when Φ = 1.11, the flow fields at the anastomosis are relatively smoother with less turbulence.

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“…One such approach is to use numerical models to calculate blood flow [13]. As blood flow through the circulatory system is pulsatile, computational studies use transient models [8,14,15]. Computational fluid dynamics (CFD) models in particular are useful because to study either static or transient blood flow, where three-dimensional models can be generated from medical images.…”

Section: Introductionmentioning

confidence: 99%

Computational analysis to predict the effect of pre-bifurcation stenosis on the hemodynamics of the internal and external carotid arteries

Bouteloup¹,

Marinho²,

Chatpun³

et al. 2020

JMES

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This study assessed the hemodynamics of a patient-specific multiple stenosed common carotid artery including its bifurcation into internal and external carotid arteries; ICA and ECA, respectively. A three-dimensional computational model of the common carotid artery was reconstructed using a process of segmentation. Computational fluid dynamics was applied with the assumption that blood is Newtonian and incompressible under pulsatile conditions through the stenotic artery and subsequent bifurcation. Blood was modelled as ‘normal’ and ‘hyperglycaemic’. A region of large recirculation was found to form at bifurcation. The asymmetric velocity flow profile through the ICA was evident through the cardiac cycle with higher velocity at the inner walls of ICA. Hyperglycaemia was found to increase wall shear stresses on the carotid artery and reduce the blood velocity by as much as 4 times in ECA. In conclusion, hemodynamics in ICA and ECA are not equally affected by stenosis, with hyperglycaemic blood potentially providing additional complications to the clinical case.

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A computational fluid dynamics simulation study of coronary blood flow affected by graft placement

Abstract: Placement and orientation of a graft may adversely affect upstream flow, with the degree of effect dependent on geometric factors of downstream position and graft angle.

Cited by 6 publications

References 7 publications

Non-Newtonian effects in simulations of coronary arterial blood flow

Non-Newtonian effects in simulations of coronary arterial blood flow

The effect of anastomotic angle and diameter ratio on flow field in the distal end-to-side anastomosis

Computational analysis to predict the effect of pre-bifurcation stenosis on the hemodynamics of the internal and external carotid arteries

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