A computational approach to explore the binding mechanism of secondary metabolites of Hamigera ingelheimensis with AgrA quorum sensing proteins
Hriday Kumar Basak,
Uttam Paswan,
Abhik Chatterjee
Abstract:Bacterial resistance to existing antibacterials can be handled by focusing on the bacterial communication system, specifically bacterial quorum sensing system. Inhibiting AgrA‐DNA binding is an effective strategy for reducing the expression of diverse genes involved with the secretion of virulence factors by the Agr quorum sensing system. Hamigera ingelheimensis, a common soil fungus, produces several bioactive secondary metabolites including avellanin C which is a well‐recognised and deeply studied quorum sen… Show more
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