A computational approach for deciphering the interactions between proximal and distal regulators in B cell differentiation
Sung-Joon Park,
Kenta Nakai
Abstract:Delineating the intricate interplay between promoter-proximal and -distal regulators is crucial for understanding the function of transcriptional mediator complexes implicated in the regulation of gene expression. The aim of the present study was to develop a computational method for accurately modeling the spatial proximal and distal regulatory interactions. Our method combined regression-based models to identify key regulators through gene expression prediction and a graph- embedding approach to detect coreg… Show more
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