A comprehensive visual report of urodynamic study in rats with spinal cord injury

Salehi‐Pourmehr, Hanieh; Mahmoudi, Javad; Vahdat, Arman Saeedi; Hajebrahimi, Sakineh; Abolhasanpour, Nasrin

doi:10.1097/cu9.0000000000000150

Cited by 1 publication

(1 citation statement)

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“…After SCI, voiding is severely impaired in rodents, which demonstrate increased bladder capacity, increased maximum detrusor contraction pressure, increased PVR, and decreased voiding efficiency [ 57 , 151 , 174 , 175 ]. Tonic dyssynergic EUS activation results in poor voiding efficiency, increased residual volumes, areflexic bladder, and sometimes complete urinary retention [ 56 , 73 , 176 ].…”

Section: Cystometric Findings In Animal Models Of Scimentioning

confidence: 99%

Assessing Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury: Animal Models in Preclinical Neuro-Urology Research

et al. 2023

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Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding function and remains one of the leading causes of morbidity after spinal cord injury (SCI). The vast majority of individuals with severe SCI develop neurogenic lower urinary tract dysfunction (NLUTD), with symptoms ranging from neurogenic detrusor overactivity, detrusor sphincter dyssynergia, or sphincter underactivity depending on the location and extent of the spinal lesion. Animal models are critical to our fundamental understanding of lower urinary tract function and its dysfunction after SCI, in addition to providing a platform for the assessment of potential therapies. Given the need to develop and evaluate novel assessment tools, as well as therapeutic approaches in animal models of SCI prior to human translation, urodynamics assessment techniques have been implemented to measure NLUTD function in a variety of animals, including rats, mice, cats, dogs and pigs. In this narrative review, we summarize the literature on the use of animal models for cystometry testing in the assessment of SCI-related NLUTD. We also discuss the advantages and disadvantages of various animal models, and opportunities for future research.

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