A Comprehensive Study to Explore Tyrosinase Inhibitory Medicinal Plants and Respective Phytochemicals for Hyperpigmentation; Molecular Approach and Future Perspectives

Abstract

Tyrosinase is acopper-containing key substance in the pigmentation of mammalian hair and skin. Melanin synthesis is influenced by variety of extrinsic and internal variables, including hormone fluctuations, inflammation, ageing, and subsequent ultraviolet light exposure. Melasma, senile lentigines, freckles, and diminished colour are all undesirable side effects of excessive melanin production. The current review provides the pursuit of effective and safe tyrosinase inhibitors derived from medicinal plants, and ascribes an updated inferences on current practices. Commercially available tyrosinase inhibitors provide an even skin tone and are used clinically to treat hyperpigmentation and related disorders. This review focuses on the mechanism of melanogenesis and on experimentally verified potent and natural tyrosinase inhibitors. Bioactive compounds such as phenols, flavonoids, stilbenes, and a few traditional herbal formulations from the Indian system of medicine, have been used since long in India and subcontinents for the effective management of melanogenesis and related problems. Scientific information was gathered from different sources of databases such as PubMed, Google Scholar, Springer, Scopus, and Science Direct, as well as the literature found in medicinal plant books. This critically summarized review ensures to aid researchers and enterprises working on tyrosinase inhibitors and on conditions associated with melanogenesis, to get one-step solutions for identifying more safe and effective natural remedies.

Chemical Composition and Skin-Whitening Activities of Siegesbeckia glabrescens Makino Flower Absolute in Melanocytes

“…Thus, there is a need for improved skin whitening agents that are more efficient and safer. Natural products, such as plants and plant extracts, are generally non-toxic and thus are promising materials for developing safe and effective agents for depigmenting or whitening the skin [23]. In the present study, we extracted SGMFAb from flowers of Siegesbeckia glabrescens Makino and investigated whether SGMFAb has skin whitening or depigmentation properties using B16BL6 cells.…”