A comprehensive study on synthesis and biological activities of Pyridazine Derivatives

Abstract

Pyridazine and its derivative are very important compounds in nitrogen containing heterocyclic compounds due to their various reported pharmacological activities such as antibacterial, muscle relaxant, anti-depressant, antidiabetic, anti-hypertensive, analgesic, anti-tumor, antiviral, nephrotropic, antiinflammatory, anti-viral, anticancer, anti-aggregative, anti-epileptic. It also serves as building block in structure of many chemical constituent of natural compounds phytopharmaceuticals such as cinnolines, phthalazines and also attracting the interest of researchers and medicinal chemist due to its privilege structure which can bear substitution/functionalization easily. Different substituted pyridazine compounds have been synthesized by researchers using different reagents and diverse synthetic route. However most of the investigations available in literature are directed to its large number of biological activities with very less discussion on its various synthetic schemes yielding different type of its derivatives. With the purpose of focusing more on this lack of recent literature this review focuses on different derivative synthesis by using different reaction schemes. Now-a-days pyridazine is serving as ligand in many known chemical reactions and scaffold for drug discovery and development. The aim of this review paper is to encourage more studies on synthesis of pyridazine derivatives which in future will play a vital role for drug discovery.

Preparation of Some New Pyrazine and Triazine Derivatives and Study of their Antimicrobial and Anticancer activities

“…The solid crude material was then filtered and recrystallized from the ethanol. The physical properties and FT-IR spectral data of compounds (6)(7)(8) are listed in Table 6.…”

“…The diazine derivatives have gained a great deal of attention in the present day as a result of their many advantageous traits. For instance, the ease with which structural alterations can be made [4], the excellent electrical and optical properties [5], and the beneficial biological activities [6]. The pyridazine, which has been known as the "wonder nucleus", as well as its derivatives, were reported because of their biological and chemical actions to have a broad variety of biological activities [7], which include potent and anti-hypertensive cardiotonic agents [8].…”

Pyridazinic Bioisosteres with Potential Applications in Medicinal Chemistry and Agriculture

“…S. aureus (1) S. Lutea (2) B. subtillis (3) P. aeruginosa (4) E. coli (5) C. albicans (6) ( * ) the series 'a' of compound is related to F, the series 'b' of compound is connected to Cl and the series 'c' of compound involve CH 3 . (1) Staphylococcus aureus.…”

“…(4) Pseudomonas aeruginosa. (5) Escherichia coli. (6) Candida albicans; Bold and underline means very active compound.…”

“…Pyridazine (1,2-diazine) and its derivatives have demonstrated interesting potential applications in different fields of science, being highly valuable materials in medicinal chemistry, opto-electronics, agriculture, etc. [4][5][6][7][8][9][10][11][12][13]. The compounds derivatives from pyridazine are invaluable scaffolds in medicinal chemistry, possessing a large range of biological activities: antibacterial, antifungal, antiplasmodial, antitubercular, antiviral, anticancer, antihypertensive, diuretic, antithrombic, anticoagulant, etc.…”