A comprehensive study of risk factors for post-operative pneumonia following resection of meningioma

Abstract

BackgroundPost-operative pneumonia (Pop) following meningioma surgery is the dominant systemic complication which could cause serious threats to patients. It is unclear whether hematological biochemical markers are independently associated with the Pop. This study attempted to perform a more comprehensive study of taking both clinical factors and hematological biomarkers into account to promote the management of patients after meningioma surgery.MethodsWe collected clinical and hematological parameters of 1156 patients undergoing meningioma resection from January 2009 to January 2013. According to whether the symptoms of pneumonia had manifested,patients were divided into the Pop group and the Non-Pop group. We analyzed the distinctions of clinical factors between the two groups. We successively performed univariate and multivariate regression analysis to identify risk factors independently associated with the Pop.Results4.4% patients infected with the Pop (51 of 1156). The median age at diagnosis of the Pop patients was significantly older than the Non-Pop group (p = 0.002). There were strike distinctions of post-operative hospital stays between two groups, with 21 days and 7 days each (p < 0.001). On multivariate analysis, tumor relapse (p < 0.001), skull base lesions (p = 0.001), intra-operative blood transfusion (p = 0.018) and cardiovascular diseases (p = 0.001) were linked with increased risk of the Pop following meningioma resection. For hematological biochemical markers, it was the factor of Red blood cell distribution width-standard deviation (RDW-SD) (OR 5.267, 95%CI 1.316, 21.078; p = 0.019) and Neutrophils lymphocytes ratio (NLR) (OR 2.081, 95%CI 1.063, 4.067; p = 0.033) that could appreciably predict the Pop.ConclusionsApart from tumor recurrence, localizations, intra-operative blood transfusion and cardiovascular diseases are independent risk factors for the Pop. We initially found hematological RDW-SD and NLR are also important predictors.

Long-Term Follow-Up and Predictors of Functional Outcome after Surgery for Spinal Meningiomas: A Population-Based Cohort Study

“…Several studies on cranial meningiomas have shown that high age is a risk factor for postoperative pneumonia, postoperative hemorrhage, venous thromboembolism and 30-day mortality [44][45][46][47]. In our cohort, sex distribution, tumor localization, Simpson grade, adjuvant treatment and postoperative complication rates were similar in elderly and nonelderly patients, in line with previously reported data [48].…”

Preoperative Neutrophil‐to‐Lymphocyte Ratio may Predict Postoperative Pneumonia in Stage I–III Gastric Cancer Patients After Curative Gastrectomy: A Retrospective Study

“…However, although Inaoka et al [19] demonstrated that preoperative PLR predicted postoperative morbidity compared with other parameters, namely NLR and PNI, few studies have assessed the relationships between postoperative complications and multiple systemic in ammatory-based prognostic parameters, namely NLR, PLR, PNI, CAR, or LCR. Furthermore, only a few studies of non-small cell lung cancer or meningioma surgery identi ed preoperative NLR as a predictor of postoperative pneumonia [33,34], and no studies identi ed preoperative NLR as a predictor of postoperative pneumonia in GC surgery. Therefore, to our knowledge, ours is the rst study revealing that preoperative NLR was one of the most useful predictors of postoperative pneumonia in stage I-III GC patients after curative gastrectomy.…”

A New Hybrid Machine Learning Approach for Prediction of Phenanthrene Toxicity on Mice

“…As far as we know, SD is a way to measure the range of changes in the number of red blood cells. It is a part of a standard completely blood count, and the significance of SD in the prediction of postoperative pneumonia (Pop) in meningiomas has attracted great attention [57]. Elevated SD values may reflect chronic systemic inflammation and malnutrition.…”