A comprehensive study and comparison of four types of zwitterionic hydrogels

Zhao, Weiqiang; Zhu, Yingnan; Zhang, Jiamin; Xu, Tong; Li, Qingsi; Guo, Hongshuang; Zhang, Jinwei; Lin, Cunguo; Zhang, Lei

doi:10.1007/s10853-018-2535-6

Cited by 42 publications

(32 citation statements)

References 43 publications

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“…However, this phenomenon could not be observed with simultaneous introduction of NH 4 Cl and proline at a comparable concentration. The difference of mechanical behavior between N x B y ‐hydrogels and N x P y ‐hydrogels was attributed to their different polymer network density, which could be confirmed by Figure S4 in the Supporting Information. The hydrogels comprised a PAAm network and a Ca‐alginate network.…”

Section: Resultsmentioning

confidence: 63%

Zwitterionic Osmolyte‐Based Hydrogels with Antifreezing Property, High Conductivity, and Stable Flexibility at Subzero Temperature

Sui

Guo

Chen

et al. 2019

Adv Funct Materials

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227

166

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Conductive hydrogels have emerged as fascinating materials applied in flexible electronics because of their integrated conductivity and mechanical flexibility. However, the large amounts of water in conductive hydrogels inevitably freeze at subzero temperature, causing a reduction of their ionic transport ability and elasticity. Herein, the bioinspired antifreezing agents—zwitterionic osmolytes (e.g., betaine, proline) are first proposed to prevent ammonium chloride‐containing Ca‐alginate/polyacrylamide hydrogels from freezing. With a facile one‐pot solvent displacement method, the zwitterionic osmolytes can displace the water molecules inside the hydrogels. Due to the excellent freeze tolerance of zwitterionic osmolytes, the resulting zwitterionic osmolyte‐based hydrogels exhibit outstanding ionic conductivity (up to ≈2.7 S m−1) at −40 °C, which exceeds the conductivities of most reported conductive hydrogels. Meanwhile, they present stable mechanical flexibility over a wide temperature range (−40 to 25 °C). More importantly, two types of the resulting hydrogel‐based flexible electronics, including a capacitive sensor and a resistive sensor, can maintain their response function at −40 °C. This work offers a new solution to fabricate conductive hydrogels with antifreezing ability, which can broaden the working temperature range of flexible electronics.

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Section: Resultsmentioning

confidence: 63%

Zwitterionic Osmolyte‐Based Hydrogels with Antifreezing Property, High Conductivity, and Stable Flexibility at Subzero Temperature

Sui

Guo

Chen

et al. 2019

Adv Funct Materials

Self Cite

227

166

View full text Add to dashboard Cite

show abstract

“…Surprisingly, PCBGU-75 and PCBGU-25 demonstrated lower compressive moduli (3.2 MPa and 36.9 MPa) and lower breaking strains (60.2% and 91.3%) than other materials. This phenomenon may be caused by the less organized 58,59 An earlier study reported that a highly chemicallycrosslinked zwitterionic polymer showed a high modulus up to 100 MPa, 60 but its breaking strain was not reported. 60 In addition, the moduli of PCBGUs are in the upper-level range of polyurethane elastomers, which have been used in medical applications, such as tubing, packaging (e.g., IV solution bags), coatings, and so-touch components.…”

Section: Compression and Rheological Propertiesmentioning

confidence: 97%

Winning the fight against biofilms: the first six-month study showing no biofilm formation on zwitterionic polyurethanes

et al. 2020

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“…In general, there are two strategies to construct a wound dressing in previous studies. − First, the dressing with superior antifouling properties can prevent protein or bacterial adsorption. For example, zwitterionic polymers present superhydrophilic and non-biofouling properties, and they would be a promising candidate for antifouling wound dressings since zwitterionic polymers contain a cationic quaternary ammonium group and an anionic group in one unit, which can bind water molecules electrostatically to induce a hydration layer for preventing protein adsorption. , Lalani and Liu demonstrated that the electrospun zwitterionic poly(sulfobetaine methacrylate) membrane exhibited high resistance to adsorption of proteins, cells, and bacteria . Second, the functional dressing with excellent antimicrobial properties can actively kill bacteria, which is fabricated by physically incorporating a bactericide, covalently grafting an antimicrobial drug, or combining with photothermal (or photodynamic) antibacterial properties .…”

Section: Introductionmentioning

confidence: 99%

An Antifouling and Antimicrobial Zwitterionic Nanocomposite Hydrogel Dressing for Enhanced Wound Healing

Dai

Zhang

Chen

et al. 2021

ACS Biomater. Sci. Eng.

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Antibacterial hydrogels have received intensive interest in soft tissue repair, especially for preventing infections associated with impaired wound healing. However, developing an inherent antibacterial hydrogel dressing with antifouling ability without causing secondary damage to repaired tissues has proven to be promising and challenging. In this work, a mussel-inspired zwitterionic sulfobetaine acrylamide hydrogel incorporated with laponite (LAP) nanoplatelets and methacrylamide dopamine (DMA) has been developed for effective wound dressings, where LAP nanoplatelets and DMA endow the hydrogel with enhanced mechanical strength and substance adhesiveness, respectively. Moreover, LAP nanoplatelets could immobilize hydrophobic curcumin to form complexes, realizing the controlled release of curcumin to provide antimicrobial activities. In vitro results showed that hydrogels did not cause obvious cytotoxicity and hemolysis, but they still can well resist bovine serum albumin (BSA) adsorption. Wound closure and histopathological experiments have been performed in vivo to evaluate the therapeutic effects of the hydrogel by a full-thickness skin defect mouse model, and the results demonstrated that infected wounds could be well closed after being treated with the hydrogel for 15 days. Meanwhile, the full re-epithelialization and total formation of new connective tissues can be clearly observed by histological analysis. Moreover, the hydrogel could be easily removed from recovered tissues without causing secondary damage. Therefore, this antifouling and antimicrobial hydrogel dressing with suitable adhesiveness would provide a new strategy for wound healing without causing secondary damage.

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A comprehensive study and comparison of four types of zwitterionic hydrogels

Cited by 42 publications

References 43 publications

Zwitterionic Osmolyte‐Based Hydrogels with Antifreezing Property, High Conductivity, and Stable Flexibility at Subzero Temperature

Zwitterionic Osmolyte‐Based Hydrogels with Antifreezing Property, High Conductivity, and Stable Flexibility at Subzero Temperature

Winning the fight against biofilms: the first six-month study showing no biofilm formation on zwitterionic polyurethanes

An Antifouling and Antimicrobial Zwitterionic Nanocomposite Hydrogel Dressing for Enhanced Wound Healing

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