A Comprehensive Review On Utilization Of Various Method In The Synthesis Of Imidazole: Methods And Strategies

Abstract

Imidazole is naturally occurring biomolecules known for their diverse biological activities like antibacterial activity, anticancer activity, antituberculosis activity, analgesic activity etc. It is a pivotal five-membered aromatic heterocycle, has garnered substantial attention in various domains, including medicinal chemistry, materials science, and beyond. This review encapsulates the conventional and most recent development in imidazole synthesis. It explores a spectrum of methodologies, encompassing classical routes, innovative strategies, and sustainable approaches. Additionally, this review emphasizes the biological significance and applications of synthesized imidazole's, underlining the necessity for proficient and eco-conscious imidazole synthesis. Imidazole, with its remarkable versatility, continues to captivate the interest of researchers and presents promising opportunities for diverse applications. The information presented in this comprehensive review article is poised to be an invaluable resource for researchers, clinicians, and pharmaceutical scientists. It will aid in the development of precise and highly biologically active imidazole derivatives, further advancing the field of medicine and pharmacology.