A  Comprehensive Review on the Genus Plumbago With Focus on Plumbago Auriculata (Plumbaginaceae)

Singh, Karishma; Naidoo, Yougasphree; Baijnath, Himansu

doi:10.21010/ajtcam.v15i1.21

Cited by 28 publications

(23 citation statements)

References 52 publications

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“…The plasmid curing activity determined extracts of Plumbago auriculata, was determined against R plasmids of several bacterial strains such as E coli, P. aeruginosa, K. pneumoniae, S. aureus, Proteus vulgaris, and Enterobacter cloacae, isolated from clinical specimens like urine and pus. Its curing efficiency in P. aeruginosa was 13%, 15% in E. coli, 32% in P. vulgaris and maximum in K. pneumoniae with 30% (Singh et al, 2018). Previously also a compound, Plumbagin (6) (5-hydroxy-2-methyl-l,4-naphthoquinone), obtained from the plant root of Plumbago zeylanica was found potent in specifically eliminating the multidrug-resistant, stringent, and conjugative plasmids from E. coli strains (Lakhmi et al, 1987).…”

Section: Plasmid Curingmentioning

confidence: 99%

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

et al. 2022

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Antimicrobial resistance in clinically important microbes has emerged as an unmet challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up lately defying the action of even the last resort of antibiotics. This has led to a huge burden in the health sectors and increased morbidity and mortality rate across the world. The dwindling antibiotic discovery pipeline and rampant usage of antibiotics has set the alarming bells necessitating immediate actions to combat this looming threat. Various alternatives to discovery of new antibiotics are gaining attention such as reversing the antibiotic resistance and hence reviving the arsenal of antibiotics in hand. Antibiotic resistance reversal is mainly targeted against the antibiotic resistance mechanisms, which potentiates the effective action of the antibiotic. Such compounds are referred to as resistance breakers or antibiotic adjuvants/potentiators that work in conjunction with antibiotics. Many studies have been conducted for the identification of compounds, which decrease the permeability barrier, expression of efflux pumps and the resistance encoding enzymes. Compounds targeting the stability, inheritance and dissemination of the mobile genetic elements linked with the resistance genes are also potential candidates to curb antibiotic resistance. In pursuit of such compounds various natural sources and synthetic compounds have been harnessed. The activities of a considerable number of compounds seem promising and are currently at various phases of clinical trials. This review recapitulates all the studies pertaining to the use of antibiotic potentiators for the reversal of antibiotic resistance and what the future beholds for their usage in clinical settings.

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Section: Plasmid Curingmentioning

confidence: 99%

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

et al. 2022

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“…and Plumbago zeylanica L. are the species that belong to genus Plumbago. Hairy calyx is a characteristic feature of this genus [1,2]. These species are native to warm temperature to tropical regions of the world [3] and have wide geographical distribution that some of species grow under saline or limestone conditions [4].…”

Section: Genusmentioning

confidence: 99%

Propagation, Phytochemistry and Pharmacology of Plumbago indica - A Review

Priyanjani

Senarath

et al. 2021

JPRI

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Aims: Plumbago indica is a medicinal plant widely grown in the tropics and temperate region to use in traditional systems of medicine. Different parts of this plant are used to treat rheumatoid arthritis, dysmenorrhea, cancer, leprosy, syphilis, rheumatism, paralysis, headache, leukoderma, enlarged glands, scabies, ophthalmia, dyspepsia, haemorrhage, piles, flatulence, loss of appetite etc. Various kinds of researches were carried out in different countries on propagation and pharmacology of this medicinal plant. Scientifically proven data were concentrated on this paper to facilitate reliable convenience data source and encourage further studies. Methodology: Scientific data published on full papers, abstracts about morphology, growth, propagation, traditional medicinal uses and pharmacology of P. indica over 70 years (1949-2020) by researchers in different countries were collected and categorized under suitable topics. Results: According to literature P. indica leaves, stems, roots contain phytochemical compound that are responsible for its medicinal properties. Tissue culture of this plant can be uses as effective propagation method to fulfill the increasing demand of raw materials (dried plant parts) for medicinal preparations as well as preserve the plant in their natural habitat. Value: P. indica is used to treat vast range of diseases in traditional medicinal systems in different countries and currently pharmacological experiments are conducting to prove it scientifically. Plumbagin present in P. indica roots was already identified as a potential anti-cancer agent and subjected to more research interest. Therefore this review article helps new researchers to get wide knowledge about the plant and its pharmacology.

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“…Out of them , three species are commonly studied ( P. indica L . , P. auriculata Lam., and P. zeylanica L.) due to their ornamental and medicinal values 4 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling and anti-fibrotic activities of Plumbago indica L. and Plumbago auriculata Lam. in thioacetamide-induced liver fibrosis in rats

Selim

Melk

Melek

et al. 2022

Sci Rep

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This study aimed at investigating the chemical composition and the hepatoprotective activities of Plumbago indica L. and P. auriculata Lam. LC–MS/MS analyses for the hydroalcoholic extracts of the aerial parts of the two Plumbago species allowed the tentative identification of thirty and twenty-five compounds from P. indica and P. auriculata, respectively. The biochemical and histopathological alterations associated with thioacetamide (TAA)-induced liver fibrosis in rats were evaluated in vivo where rats received the two extracts at three different dose levels (100, 200 and 400 mg/kg p.o, daily) for 15 consecutive days with induction of hepatotoxicity by TAA (200 mg/kg/day, i.p.) at 14th and 15th days. Results of the present study showed a significant restoration in liver function biomarkers viz. alanine transaminase (ALT), aspartate transaminase (AST), gamma glutamyl transferase and total bilirubin. The liver homogenates exhibited increased levels of antioxidant biomarkers: reduced glutathione (GSH) and catalase (CAT), accompanied with decline in malondialdehyde (MDA). Furthermore, treated groups exhibited a significant suppression in liver inflammatory cytokines: tumor necrosis factor-α (TNF-α) and interlukin-6 (IL-6), and fibrotic biomarker: alpha smooth muscle relaxant. Histopathological examination of the liver showed normality of hepatocytes. Noteworthy, P. indica extract showed better hepatoprotective activity than P. auriculata, particularly at 200 mg/kg. To sum up, all these results indicated the hepatoprotective properties of both extracts, as well as their antifibrotic effect was evidenced by reduction in hepatic collagen deposition. However, additional experiments are required to isolate their individual secondary metabolites, assess the toxicity of the extracts and explore the involved mechanism of action.

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A Comprehensive Review on the Genus Plumbago With Focus on Plumbago Auriculata (Plumbaginaceae)

Cited by 28 publications

References 52 publications

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

Propagation, Phytochemistry and Pharmacology of Plumbago indica - A Review

Phytochemical profiling and anti-fibrotic activities of Plumbago indica L. and Plumbago auriculata Lam. in thioacetamide-induced liver fibrosis in rats

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