A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

Chaudhuri, Tapas Kumar; Roy, Swarnendu

doi:10.31579/2693-7247/014

Cited by 7 publications

(5 citation statements)

References 28 publications

(38 reference statements)

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“…Different types of D. esculentum solvent extractions have been investigated regarding their pharmacological properties, especially for neuromodulatory effects both in vitro and in vivo [ 30 ]. D. esculentum ethanolic extract (1.25 mg/mL) inhibited AChE, BChE, and BACE-1 at 46.15, 53.12, and 55.91% [ 17 ], while a 70% methanolic extract inhibited AChE with an IC 50 value of 272.97 µg/mL [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fortunately, kaempferol, quercetin, and rosmarinic acid-the top three phytochemicals found in DE (Table 1)-have also been reported to cross the BBB [29], highlighting the possibility that these compounds contributed to the rough eye improvement in Drosophila (Figure 5). Different types of D. esculentum solvent extractions have been investigated regarding their pharmacological properties, especially for neuromodulatory effects both in vitro and in vivo [30]. D. esculentum ethanolic extract (1.25 mg/mL) inhibited AChE, BChE, and BACE-1 at 46.15, 53.12, and 55.91% [17], while a 70% methanolic extract inhibited AChE with an IC 50 value of 272.97 µg/mL [31].…”

Section: Discussionmentioning

confidence: 99%

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Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer’s Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

Inthachat,

Chantong,

Pitchakarn

et al. 2024

Pharmaceuticals

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Alzheimer’s disease (AD) is the most common type of dementia and a significant concern to global public health due to the prevalence of aging populations. Donepezil is one of only a few medications approved for use as an anti-AD agent but all have adverse side effects. Reducing the dosage of AD drugs with plant extracts (phytotherapy) while maintaining efficacy is one strategy to minimize adverse side effects. We previously reported the anti-AD properties of an edible fern, Diplazium esculentum (Retz.) Sw. (DE), which inhibited key enzymes involved in AD pathogenesis including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase 1 (BACE-1). This study aimed to determine whether DE exhibited a synergistic effect with donepezil. The enzyme inhibitory assay showed that DE extract and its bioactive compounds, kaempferol, and quercetin, slightly impeded AChE inhibition with donepezil, while DE extract and quercetin showed synergistic or additive effects with donepezil against BChE and BACE-1, respectively. DE extract combined with donepezil also improved eye phenotypes in a Drosophila model of AD by preventing ommatidia atrophia and bristle breakages. Furthermore, the DE extract exhibited no genotoxic activities, as determined by the Ames test. Our data revealed that DE extract showed promise when combined with donepezil during AD treatment by targeting BChE and BACE-1.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer’s Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

Inthachat,

Chantong,

Pitchakarn

et al. 2024

Pharmaceuticals

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“…The plant possesses antiin ammatory and antioxidant chemicals that can help cure topical dermatitis and decrease in ammation and oxidative stress in the skin. It also has a poisonous impact on insects through contact poisoning, respiratory accretion, and acetylcholinesterase inhibition (Roy & Chaudhuri, 2020;Semwal et al, 2021).…”

Section: Dicksonia Blumei (Kunze) Moorementioning

confidence: 99%

Ethnopharmacology and Species diversity of Pteridophyta in Cyathea Park, Bali: A Field study and Literature Review

Juliasih

Adnyana

2023

Preprint

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Pteridophyta has been studied and conserved at the botanical garden. However, few have found and documented the medicinal properties of Pteridophyta species. The study identified species diversity and ethnopharmacology of Pteridophyta collected in Cyathea Park, Bali. Field exploration research and literature review were used in this study. The research was conducted by directly exploring the species of Pteridophyta collected in Cyathea Park, Bali and literature studies on the benefits and ethnopharmacology of Pteridophyta species are used as candidates and raw materials for traditional medicine. Data search is carried out systematically by utilizing databases and keywords. All the data is examined qualitatively and descriptively. The study's findings indicate nine species: Cyathea contaminans (Wall.ex Hook) Copel, Asplenium nidus L., Asplenium sp., Selaginella sp., Diplazium esculentum., Angiopteris evecta (G.Forst.) Hoffm, Cyatheasp., Nephrolepis hirsutula (Forst), and Dicksonia blumei (Kunze) Moore. The leaves and shoots are the most frequently used raw materials in medicine. At the same time, the roots, stems, and hair are utilized in planting mediums, crafts, games, and food production. Pteridophyta species treat fever, cough, anticonvulsant, antibacterial, anti-inflammatory, antipyretic, antidiuretic, antioxidant, insecticide, larvicide, diabetes, and anti-retroviral. As many as nine identified species Pteridophyta in Cyathea Park, Bali has benefits as traditional medicinal agents and has been widely used by the people as the culture of the archipelago. Its pharmacological, phytochemical and toxicity properties need further investigations.

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“…The plant possesses anti-inflammatory and antioxidant chemicals that can help cure topical dermatitis and decrease inflammation and oxidative stress in the skin. It also has a poisonous impact on insects through contact poisoning, respiratory accretion, and acetylcholinesterase inhibition (Roy and Chaudhuri, 2020;Semwal et al, 2021).…”

Section: Meta-synthesis Related To Therapeutic Benefits Biological Ac...mentioning

confidence: 99%

Utilization of Pteridophyta species in Cyathea Park, Bali, as traditional medicine agents: A field study and meta-synthesis review

Juliasih

Adnyana

2023

Not Sci Biol

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Pteridophytes have been studied and preserved in botanical gardens. However, only a few have discovered and documented the medicinal properties of Pteridophyta species. This study aims to promote the utilization of Pteridophyta species in Taman Cyathea, Bali, as traditional medicine agents by conducting a comprehensive literature review with a novelty of 15 years (2008-2022) on the ethnopharmacology and species diversity of the plant division. This research was conducted by directly exploring Pteridophyta species collected in Taman Cyathea, Bali, and a meta-synthesis was carried out related to the potential use of these species as traditional medicinal agents. The STARLITE principle was used for the article search, and ENTREQ was used for transparency in reporting meta-synthetic results. The study was conducted by searching the databases with keywords set according to the inclusion criteria. Findings in the field showed that there were as many as nine species of Pteridophyta identified as having benefits as traditional medicine agents, including Cyathea contaminans (Wall ex Hook) Copel., Asplenium nidus L., Asplenium sp., Selaginella sp., Diplazium esculentum, Angiopteris evecta (G.Forst.) Hoffm, Cyathea sp., Nephrolepis hirsutula (Forst) C. Presl and Dicksonia blumei (Kunze) Moore. The results of the meta-synthesis obtained 49 articles that met the study criteria; leaves, shoots, roots, stems, and hairs were used for various purposes, including restorative materials, planting media, crafts, game materials, and food ingredients. Pteridophyta species treat fever, cough, anticonvulsant, antibacterial, anti-inflammatory, antipyretic, antidiuretic, immunomodulatory, antioxidant, insecticide, larvicide, diabetes, and antiretroviral diseases, among others, so their potential use as traditional medicine agents and candidates for standardized herbs or phytopharmaceuticals have promising prospects in the future. However, its pharmacological, phytochemical, and toxicity properties must be investigated further.

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A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

Cited by 7 publications

References 28 publications

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer’s Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer’s Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

Ethnopharmacology and Species diversity of Pteridophyta in Cyathea Park, Bali: A Field study and Literature Review

Utilization of Pteridophyta species in Cyathea Park, Bali, as traditional medicine agents: A field study and meta-synthesis review

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