A comprehensive review on the ethnobotany, phytochemistry, pharmacology and quality control of the genus <i>Lycium</i> in China

Yu, Zhonglian; Xia, Mengqin; Lan, Jiping; Li, Yang; Wang, Zhengtao; Wang, Rui; Tao, Hongxun; Shi, Yanhong

doi:10.1039/d2fo03791b

Cited by 11 publications

(12 citation statements)

References 103 publications

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“…Contains rutin and chlorogenic acid [101]. It also contains various polysaccharides, carotenoids, alkaloids, and phenolic compounds [102].…”

Section: Lycium Chinensementioning

confidence: 99%

Insights into How Plant-Derived Extracts and Compounds Can Help in the Prevention and Treatment of Keloid Disease: Established and Emerging Therapeutic Targets

Boo

2024

IJMS

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Keloid is a disease in which fibroblasts abnormally proliferate and synthesize excessive amounts of extracellular matrix, including collagen and fibronectin, during the healing process of skin wounds, causing larger scars that exceed the boundaries of the original wound. Currently, surgical excision, cryotherapy, radiation, laser treatment, photodynamic therapy, pressure therapy, silicone gel sheeting, and pharmacotherapy are used alone or in combinations to treat this disease, but the outcomes are usually unsatisfactory. The purpose of this review is to examine whether natural products can help treat keloid disease. I introduce well-established therapeutic targets for this disease and various other emerging therapeutic targets that have been proposed based on the phenotypic difference between keloid-derived fibroblasts (KFs) and normal epidermal fibroblasts (NFs). We then present recent studies on the biological effects of various plant-derived extracts and compounds on KFs and NFs. Associated ex vivo, in vivo, and clinical studies are also presented. Finally, we discuss the mechanisms of action of the plant-derived extracts and compounds, the pros and cons, and the future tasks for natural product-based therapy for keloid disease, as compared with existing other therapies. Extracts of Astragalus membranaceus, Salvia miltiorrhiza, Aneilema keisak, Galla Chinensis, Lycium chinense, Physalis angulate, Allium sepa, and Camellia sinensis appear to modulate cell proliferation, migration, and/or extracellular matrix (ECM) production in KFs, supporting their therapeutic potential. Various phenolic compounds, terpenoids, alkaloids, and other plant-derived compounds could modulate different cell signaling pathways associated with the pathogenesis of keloids. For now, many studies are limited to in vitro experiments; additional research and development are needed to proceed to clinical trials. Many emerging therapeutic targets could accelerate the discovery of plant-derived substances for the prevention and treatment of keloid disease. I hope that this review will bridge past, present, and future research on this subject and provide insight into new therapeutic targets and pharmaceuticals, aiming for effective keloid treatment.

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“…Contains rutin and chlorogenic acid [101]. It also contains various polysaccharides, carotenoids, alkaloids, and phenolic compounds [102].…”

Section: Lycium Chinensementioning

confidence: 99%

Insights into How Plant-Derived Extracts and Compounds Can Help in the Prevention and Treatment of Keloid Disease: Established and Emerging Therapeutic Targets

Boo

2024

IJMS

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“…Out of these, 14 are synonymous mutations, meaning they do not change the amino acid sequence. With the exception of the SNP at position 1312, situated within a codon that encodes for lysine/arginine (basic amino acids), the rest of the SNPs are situated within codons that encode for either nonpolar (10) or polar amino acids (11), and none of these SNPs change the polarity or charge of the encoded amino acid. A key finding was the apparent distinction in most SNPs between the cultivated and wild varieties of the plant, with differences being observed as homozygous versus heterozygous SNPs.…”

Section: Sequence Analyses Of Bodyguard Genes In Romanian Goji Berry ...mentioning

confidence: 99%

“…Its oxygen radical absorbance capacity values, which lie between 25,000 and 30,000, surpass those of other nutritionally beneficial fruits like pomegranates and blueberries, indicating its superior antioxidant capacity [6]. Its medicinal uses range from improving visual acuity [5,7,8], abdominal pain [5], dry cough, fatigue and headache [5], immune system support, cancer prevention [7,8], and antidiabetic activity [7,8] to increased longevity [8][9][10] and enhanced fertility [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Genomic Analysis of Romanian Lycium Genotypes: Exploring BODYGUARD Genes for Stress Resistance Breeding

Ciceoi,

Asanica,

Luchian

et al. 2024

IJMS

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Goji berries, long valued in Traditional Chinese Medicine and Asian cuisine for their wide range of medicinal benefits, are now considered a ‘superfruit’ and functional food worldwide. Because of growing demand, Europe and North America are increasing their goji berry production, using goji berry varieties that are not originally from these regions. European breeding programs are focusing on producing Lycium varieties adapted to local conditions and market demands. By 2023, seven varieties of goji berries were successfully registered in Romania, developed using germplasm that originated from sources outside the country. A broader project focused on goji berry breeding was initiated in 2014 at USAMV Bucharest. In the present research, five cultivated and three wild L. barbarum genotypes were compared to analyse genetic variation at the whole genome level. In addition, a case study presents the differences in the genomic coding sequences of BODYGUARD (BDG) 3 and 4 genes from chromosomes 4, 8, and 9, which are involved in cuticle-related resistance. All three BDG genes show distinctive differences between the cultivated and wild-type genotypes at the SNP level. In the BDG 4 gene located on chromosome 8, 69% of SNPs differentiate the wild from the cultivated genotypes, while in BDG 3 on chromosome 4, 64% of SNPs could tell the difference between the wild and cultivated goji berry. The research also uncovered significant SNP and InDel differences between cultivated and wild genotypes, in the entire genome, providing crucial insights for goji berry breeders to support the development of goji berry cultivation in Romania.

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“…Plants 2024, 13, x FOR PEER REVIEW 2 of 24 potentially extending lifespans [5][6][7]. Although they contain a rich array of nutrients, including carbohydrates, vitamins, amino acids, inorganic salt, high-molecular polysaccharides, enzymes, and other biologically active ingredients, there are differences not only in the color of the fruit but also in their composition among the different species of goji berries [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

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Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as “red Goji berries” or “black Goji berries” due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development.

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A comprehensive review on the ethnobotany, phytochemistry, pharmacology and quality control of the genus Lycium in China

Abstract: The genusLycium, perennial herbs of the Solanaceae family, has been an important source of medicines and nutrient supplements for thousands of years in China, where seven species and three...

Cited by 11 publications

References 103 publications

Insights into How Plant-Derived Extracts and Compounds Can Help in the Prevention and Treatment of Keloid Disease: Established and Emerging Therapeutic Targets

Insights into How Plant-Derived Extracts and Compounds Can Help in the Prevention and Treatment of Keloid Disease: Established and Emerging Therapeutic Targets

Genomic Analysis of Romanian Lycium Genotypes: Exploring BODYGUARD Genes for Stress Resistance Breeding

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

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