A comprehensive review on the ethnobotanical, phytochemical, and pharmacological aspects of the genus Malvastrum

Sheema,; Zafar, Salman; Uddin, Ghias; Rashid, Afsana

doi:10.1016/j.fitote.2023.105666

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…It is made up of about two hundred and fifty (250) genera and over four thousand (4000) species (Xu & Deng, 2017). Numerous ethno-botanical uses of different parts of the plants belonging to this family have been documented (Sheema et al, 2023). They are used as diuretic and demulcent, equally employed in the treatment of fevers, chest infections, gonorrhea, urethritis and bleeding piles.…”

Section: Introductionmentioning

confidence: 99%

Screening and Chromatographic identification of the phytochemicals in the Powdered leaves of <i>Urena lobata</i> L. (Malvaceae)

Odion,

Ambe,

Odiete

et al. 2024

dujopas

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Urena lobata is a widely distributed tropical and subtropical weed with varying pharmacological activities, ascribed to the presence of bioactive principles in the plant. This study aimed to identify phytochemicals in the powdered leaves of Urena lobata using two chromatographic techniques. Phytochemical screening was evaluated for the powdered leaves using standard methods, Gas Chromatography-Mass Spectrometry (GC-MS) and High Pressure Liquid Chromatography (HPLC) were utilized to determined the phytochemicals in the methanolic extract of the leaves. Results obtained indicate that alkaloids, cyanogenic glycosides, flavonoids, saponins, steroids, tannins and terpenoids were detected in the methanolic extract of the leaves. The GC-MS analysis showed the presence of 4-(3-dimethylaminopropoxy)benzaldehyde, pyridine, 9-octadecenamide, 2-amino-5-chlorophenyl phosphonic acid, 2-propenenitrile, 2,1-benzisoxazole-4-carboxlic acid, 1,2,4-triazin-5(2H)-one, pyridine-3-carboxamide, 2-pyrazoline, 4-aminobenzoic acid, 3-nitrophthalhydrazide, 2,4 (1H, 5H)-imidazoldione and bromophos-ethyl, semicarbazide. While the HPLC analysis for selected alkaloids detected imidazole and pyrazoline alkaloidal moieties from the extract. Owing to the results obtained in this study, it can be concluded that phytochemicals of important pharmacological potentials were detected in the methanolic extract of Urena lobata leaves.

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Section: Introductionmentioning

confidence: 99%

Screening and Chromatographic identification of the phytochemicals in the Powdered leaves of <i>Urena lobata</i> L. (Malvaceae)

Odion,

Ambe,

Odiete

et al. 2024

dujopas

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Malvastrum coromandelianum Mediated Bio-Fabrication of MgO: ZnO Nanocomposites and Their Biological Potential

Sheema,

Jamal,

Uddin

et al. 2024

J Inorg Organomet Polym

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A bitter flavonoid gum from Dorema aucheri accelerate wound healing in rats: Involvement of Bax/HSP 70 and hydroxyprolin mechanisms

Ahmed,

Jabbar,

Raouf

et al. 2024

Skin Research and Technology

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BackgroundDorema aucheri gum (DAG) is a bitter flavonoid gum widely used for numerous medicinal purposes including wound recovery. The present work investigates the acute toxicity and wound‐healing effects of DAG in excisional skin injury in rats.Materials and methodsSprague Dawley rats (24) were clustered into four groups, each rat had a full‐thickness excisional dorsal neck injury (2.00 cm) and addressed with 0.2 mL of the following treatments for 15 days: Group A (vehicle), rats addressed with normal saline; Group B, rats received intrasite gel; C and D, rats addressed with 250 and 500 mg/kg of DAG, respectively.ResultsThe results revealed the absence of any toxic signs in rats who received oral dosages of 2 and 5 g/kg of DAG. Wound healing was significantly accelerated following DAG treatments indicated by smaller open areas and higher wound contraction percentages compared to vehicle rats. Histological evaluation revealed higher fibroblast formation, collagen deposition, and noticeably lower inflammatory cell infiltration in granulated skin tissues of DAG‐addressed rats compared to vehicle rats. DAG treatment caused significant modulation of immunohistochemical proteins (decreased Bax and increased HSP 70) and inflammatory mediators (reduced TNF‐α, IL‐6, and magnified IL‐10), which were significantly varied compared to vehicle rats. Moreover, topical DAG treatment led to significant upregulation of the hydroxyproline (HDX) (collagen) and antioxidant content. At the same time, decreased the lipid peroxidation (MDA) levels in healed tissues obtained from DAG‐treated rats.ConclusionThe present wound contraction by DAG might be linked with the modulatory effect of its phytochemicals (polysaccharides, flavonoids, and phenolic) on the cellular mechanisms, which justify their folkloric use and provokes further investigation as therapeutic drug additives for wound contraction.

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A comprehensive review on the ethnobotanical, phytochemical, and pharmacological aspects of the genus Malvastrum

Cited by 3 publications

References 28 publications

Screening and Chromatographic identification of the phytochemicals in the Powdered leaves of <i>Urena lobata</i> L. (Malvaceae)

Screening and Chromatographic identification of the phytochemicals in the Powdered leaves of <i>Urena lobata</i> L. (Malvaceae)

Malvastrum coromandelianum Mediated Bio-Fabrication of MgO: ZnO Nanocomposites and Their Biological Potential

A bitter flavonoid gum from Dorema aucheri accelerate wound healing in rats: Involvement of Bax/HSP 70 and hydroxyprolin mechanisms

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