This chapter offers a comprehensive overview of agrochemicals in modern agriculture. Agrochemicals, including fertilizers, herbicides, insecticides, and fungicides, are vital for boosting crop yields, managing pests, and enhancing farm productivity. While they have contributed to addressing global food security challenges since the Green Revolution, their improper and excessive use raises concerns of environmental contamination, soil degradation, and harm to nontarget organisms. Climate change adds further complexities to agrochemical use. To ensure long-term sustainability, integrated pest management, precision agriculture, and eco-friendly alternatives should be embraced. Responsible agrochemical use must be prioritized by farmers and policymakers, considering potential environmental and health impacts. By balancing the benefits and risks, we can work towards a more sustainable future in agriculture, ensuring food availability while safeguarding the environment.