A comprehensive review on Schisandrin and its pharmacological features

Wang, Xiaohu; Wang, Xingwen; Yao, Hui; Shen, Chaozhuang; Geng, Kuo; Xie, Haitang

doi:10.1007/s00210-023-02687-z

Cited by 7 publications

(7 citation statements)

References 72 publications

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“…These reactions have attracted much attention due to their ability to produce complex polycyclic structures ( e.g. natural products, pharmaceuticals, or valuable intermediates) 11–55 (Scheme 1).…”

Section: From Classical Cycloadditions To Higher-order Cycloadditionsmentioning

confidence: 99%

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Zhang,

Wang

2024

Org. Chem. Front.

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Section: From Classical Cycloadditions To Higher-order Cycloadditionsmentioning

confidence: 99%

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Zhang,

Wang

2024

Org. Chem. Front.

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“…Jia et al, 2023;Wang et al, 2024;Zhou et al, 2021). We propose that the most active component of S. chinensis berry extract may be schisandrin, which could be the major determinant of its anti-platelet activity in vitro.…”

mentioning

confidence: 92%

“…also found that schisandrin promotes the recovery of myocardial tissues by enhancing cell viability and migration. Recently, more information about the protective effect of schisandrin on the cardiovascular system has been described in a review paper by(Wang et al, 2024). However, it did not cover the effect of this compound on blood platelets.Researchers have incorporated schisandrin as a key ingredient in various formulations, including tablets, capsules, liquids, and injections, to investigate its e cacy.…”

mentioning

confidence: 99%

“…Interestingly, schisandrin exhibited a good level of absorption. Hydroxylation and demethylation pathways are its main metabolic modi cations(Wang et al, 2024).Another active components that we identi ed in S. chinensis berries are triterpenoids, which display a wide range of biological activities, including antitumor, antiviral, hepatoprotective, neuroprotective, and anti-in ammatory (…”

mentioning

confidence: 99%

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Phytochemical analysis of the extract from berries of Schisandra chinensis Turcz. (Baill.) and its anti-platelet potential in vitro

Sławińska,

Kontek,

Żuchowski

et al. 2024

Preprint

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Schisandra chinensis Turcz. (Baill.) is a dioecious vine, belonging to the Schisandraceae family. Itsberries show several beneficial activities, including cardioprotective, antioxidant, and anti-inflammatory. We examined the chemical content of the extract from S. chinensis berries, as well as its antiplatelet potential in washed human blood platelets and whole blood in vitro. We assessed effect of the extract on several hemostasis parameters, including thrombus formation in full blood, platelet activation and adhesion, and coagulation times. Moreover, we evaluated the cytotoxicity of the extract against blood platelets based on extracellular lactate dehydrogenase (LDH) activity. The most important constituents of the extract were dibenzocyclooctadiene lignans; schisandrin was the dominant compound. The extract inhibited thrombus formation, agonist-stimulated platelet activation and adhesion, and was not cytotoxic. These results suggest that S. chinensisberries can be used as a safe, natural supplement with anti-platelet properties. However, more studies are needed to determine their mechanisms of action and in vivo efficiency.

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“…Dihydroisoquinolines (DHIQs) display a wide range of bioactivities on antitumor, antifungal, vasodilation, and nonoamine oxidase inhibition, which demonstrate high potential applications in the pharmaceutical industry. − The present synthetic routes for DHIQs are based on thermal/photocatalytic strategies carried out in organic solvents, suffering from low selectivity. The fully dehydrogenated products (isoquinolines, IQs) are usually obtained but with a low selectivity for DHIQs. − …”

Section: Introductionmentioning

confidence: 99%

Surface Reconstruction for Selective Oxidation of Tetrahydroisoquinoline

Chen,

Zhang,

Sun

et al. 2024

Inorg. Chem.

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Integration of hydrogen evolution with the oxidation of organic substances in one electrochemical system is highly desirable. However, achieving selective oxidation of organic substances in the integrated system is still highly challenging. In this study, a phosphorylated NiMoO 4 nanoneedle-like array was designed as the catalytic active electrode for the integration of highly selective electrochemical dehydrogenation of tetrahydroisoquinolines (THIQs) with hydrogen production. The leaching of anions, including MoO 4 2− and PO 4 3− , facilitates the reconstruction of the catalyst. As a result, nickel oxyhydroxides with the doping of PO 4 3− and richness of defects are in situ formed. In situ Raman and density functional theory calculations have shown that the high catalytic activity is attributed to the in situ formed PO 43− involved NiOOH substance. In the dehydrogenation process, the involved C−H bond but not the N−H bond is first destroyed. A two-electrode system was then fabricated with the optimized electrode that shows a benchmark current density of 10 mA cm −2 at 1.783 V, providing a yield of 70% for dihydroisoquinolines. A robust stability was also shown for this integrated electrochemical system. The understanding of the reconstruction behavior and the achievement of selective dehydrogenation will provide some hints for electrochemical synthesis.

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A comprehensive review on Schisandrin and its pharmacological features

Cited by 7 publications

References 72 publications

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Phytochemical analysis of the extract from berries of Schisandra chinensis Turcz. (Baill.) and its anti-platelet potential in vitro

Surface Reconstruction for Selective Oxidation of Tetrahydroisoquinoline

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