A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

Self-Assembly of Sulfate-Containing Peptides Sequesters VEGF for Inhibiting Cancer Cell Invasion

“…In recent years, self-assembling peptides have emerged as versatile tools for designing functional biomaterials with tunable properties. − These peptides possess the unique ability to spontaneously form well-defined nanostructures through noncovalent interactions, offering a platform for creating structurally defined nanostructures that can mimic natural extracellular matrix components. , Drawing inspiration from the structural motifs of HS, several sulfated peptides have been developed as binding partners to growth factors including VEGF, , transforming growth factor-β1 (TGF-β1), bone morphogenic protein-4 (BMP4), , hepatocyte growth factor (HGF), and fibroblast growth factor-2 (FGF-2). ,, However, their potentials to inhibit cancer metastasis have yet to be confirmed.…”

Self-assembly of peptide nanomaterials at biointerfaces: molecular design and biomedical applications

“…26,27 As a result, peptide assemblies exhibit greater stability, distinctive mechanical properties, and a wider range of biological activities compared to their monomeric counterparts. 28–30 “ In vivo self-assembly” is a new technique firstly proposed for constructing nanomaterials in situ within living organisms in 2015. 31 Self-assembled peptides, as a type of nanomaterial, can undergo four sequential transport processes in vivo , including targeting, penetration, accumulation, and clearance, which are determined by their site of action.…”

pH-Responsive Co-Assembled Peptide Hydrogel to Inhibit Drug-Resistant Bacterial Infection and Promote Wound Healing

“…Supramolecular hydrogels based on amphiphilic peptides (AMPs) and their derivatives have received much attention as biofunctional materials. − Polymer hydrogels have characteristic limitations such as leading to adverse effects and even toxicity . In contrast, self-assembled peptide hydrogels exhibit better biocompatibility and biodegradability and are more easily processed physiologically. , Various peptide sequences and structures have been used to construct self-assembled hydrogels; given their biocompatibility and minimal immunity, they are widely used in biomineralization, drug delivery, cell culture, and biosensing. − AMPs self-assemble into supramolecular hydrogels through noncovalent π–π, charge-based, hydrophobic, and hydrogen bonding interactions and van der Waals forces. , In the development of peptide-based drug delivery systems, environmental factors at the lesion site (temperature, enzymes, , and organic solvents) are used to trigger self-assembly and ensure precise drug delivery. The enzyme-instructed self-assembly technique has been developed to create bioactive nanomaterials for use in biology and medicine. , The hydrogels can also be formed via the co-assembly of AMPs with drugs to achieve controlled release rather than single concentration-dependent diffusion. − Curcumin (Cur) is a yellow polyphenolic compound extracted from turmeric.…”

“…22−24 AMPs self-assemble into supramolecular hydrogels through noncovalent π−π, charge-based, hydrophobic, and hydrogen bonding interactions and van der Waals forces. 25,26 In the development of peptide-based drug delivery systems, environmental factors at the lesion site (temperature, 27 enzymes, 28,29 and organic solvents 30 ) are used to trigger selfassembly and ensure precise drug delivery. The enzymeinstructed self-assembly technique has been developed to create bioactive nanomaterials for use in biology and medicine.…”