A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals

Abstract

Oral route of administration is widely accepted and desired because of its versatility, convenience, and most importantly patient compliance. Multiparticulate systems like granules and pellets are more advantageous when compared to single-unit dosage forms, as they are capable to distribute the drug more evenly in the gastrointestinal tract. The current paper focuses on pellets, the merits and demerits associated, various pelletization techniques, and its characterization. It also focuses on how pellets can be employed for drug delivery in controlled and sustained release formulations. It gives a com-plete emphasis on the drug and excipients that can be used in pellet formation, the marketed formulations, and the research pertaining to pellets.

The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium

“…Such drug-layered pellets (multiparticulates) can be placed in hard capsule shells or sachets and are intended to be sprinkled onto a teaspoon or tablespoon of soft food or liquid and swallowed immediately without chewing. The drug substance is contained in many independent units, which makes the formulation very flexible, so that the dose of the drug can be regulated only by the mass of the RSC multiparticulates applied [ 33 , 34 , 35 ].…”

Release of molecules from nanocarriers

“…Usually, it occurs from macroscopic pellets (reviewed in ref. 1–3). Nowadays, however, attention is shifted to the fabrication of novel drugs and antiviral vaccines based, e.g.…”

“…Usually, it occurs from macroscopic pellets (reviewed in ref. [1][2][3]. Nowadays, however, attention is shifted to the fabrication of novel drugs and antiviral vaccines based, e.g., on RNA (mRNA or siRNA) delivery by nanocarriers such as 100 nm-sized lipid nanoparticles (LNPs; reviewed in ref.…”

Formulation and Evaluation of Probiotic and Prebiotic Loaded Pellets by Extrusion and Spheronization for Improved Storage Viability

“…Avicel® PH-101 was used as the pelletizing agent as it has been proven to have the optimum extrudable characteristics for the wet mass [13]; however, it possesses a drawback of not disintegrating completely; hence, to overcome this issue a super disintegrant and a binder Polyvinyl pyrrolidone [14] was used in a concentration of 5% in all the formulations. Inulin and Pectin [15][16][17] have been used in various formulations of probiotic strains [18] to improve their viability during the transition to GIT and storage conditions [19].…”