“…Therefore, the elevated WBC count in the treatment groups indicates that the polyherbal recipe employed in the study may possess immune-enhancing properties 88,89 . Furthermore, the LYM results indicate an enhanced defense mechanism in mice against tumor cell growth 90 . The decrease in basophil and neutrophil counts suggests that the extract recipe have a curative and suppressive effect.…”
Antitumor chemotherapeutic drugs used in lung cancer management cause many adverse effects like damage to healthy cells and tumor relapse. Chemo-therapeutic agents fails to provide a complete cure due to single drug dose. Hence, new treatment, particularly phytotherapy is needed to reduce the side effects. Herein, the synergistic effect of a polyherbal (Phyllanthus amarus, Euphorbia hirta, and Azadirachta indica) recipe was evaluated to determine its suppressive effects at different doses against benzo(a)pyrene (BaP)-induced lung cancer in albino mice. The phytochemical and safety of the recipe using cytogenetic, heamatology and histology indices were also evaluated. High concentration of phenols (158.27%), flavonoids (36.41%) and low concentration of cardenolides and steroids in the extract were identified. BaP exposure induced elevated lipid peroxidation and decreased antioxidant enzyme activity. Significant increase of WBCs and LYM at 100 and 200 mg/kg were observed. The recipe also demonstrated protective effects on liver and kidney biomarkers, and reduction in micronucleus formation, counteracting potential BaP-induced damage. Severe damage in the BaP-treated group lung tissues were observed but the recipe treated groups exhibited reduced damages. The study highlighted the efficacy of the recipe in preventing lung carcinogenesis, underscoring its potential as a preventive measure with curative and anti-proliferative properties.
“…Therefore, the elevated WBC count in the treatment groups indicates that the polyherbal recipe employed in the study may possess immune-enhancing properties 88,89 . Furthermore, the LYM results indicate an enhanced defense mechanism in mice against tumor cell growth 90 . The decrease in basophil and neutrophil counts suggests that the extract recipe have a curative and suppressive effect.…”
Antitumor chemotherapeutic drugs used in lung cancer management cause many adverse effects like damage to healthy cells and tumor relapse. Chemo-therapeutic agents fails to provide a complete cure due to single drug dose. Hence, new treatment, particularly phytotherapy is needed to reduce the side effects. Herein, the synergistic effect of a polyherbal (Phyllanthus amarus, Euphorbia hirta, and Azadirachta indica) recipe was evaluated to determine its suppressive effects at different doses against benzo(a)pyrene (BaP)-induced lung cancer in albino mice. The phytochemical and safety of the recipe using cytogenetic, heamatology and histology indices were also evaluated. High concentration of phenols (158.27%), flavonoids (36.41%) and low concentration of cardenolides and steroids in the extract were identified. BaP exposure induced elevated lipid peroxidation and decreased antioxidant enzyme activity. Significant increase of WBCs and LYM at 100 and 200 mg/kg were observed. The recipe also demonstrated protective effects on liver and kidney biomarkers, and reduction in micronucleus formation, counteracting potential BaP-induced damage. Severe damage in the BaP-treated group lung tissues were observed but the recipe treated groups exhibited reduced damages. The study highlighted the efficacy of the recipe in preventing lung carcinogenesis, underscoring its potential as a preventive measure with curative and anti-proliferative properties.
“…All the parts of this plant are employed in traditional medicine [3,6]. The roots and the leaves of R. vomitoria are consumed as tisane and employed ethno medicinally for hypertension, insanity, depression and cholera [3,7,8]. In Nigeria, it also has reputation for treating fever and as an antidote for snakebite.…”
Section: Rauvolfia Vomitoriamentioning
confidence: 99%
“…About 50 alkaloids have been isolated from this plant, among which are reserpine, ajmaline, deserpidine, corynanthine, rescinnamine and yohimbine [3,17,18]. The Genus Rauvolfia comprises several species including the African Rauvolfia vomitoria which are more distributed across the tropical regions of the World [19]. In Nigeria [20,21] as well as other tropical African countries [22].…”
This study was aimed at documenting some pharmacognostic and peptidomic standards on the leaf of Nigerian species of Rauvolfia vomitoria Wennberg (RVM). Using standard methods, the fresh and dried pulverized leaves of R. vomitoria were standardized macroscopically and microscopically, in addition to the physiochemical evaluation and MALDI TOF/TOF-guided peptidomic screening of the aqueous extracts of the leaf. The leaf is simple, elliptical shaped, crenated margin which is acute. The leaf presented a hexagonal shaped epidermal cell on both sides with anomocytic stomata only on the abaxial surface making it hypostomatous while stomata number and index are 15 – 16 – 18 and 24 – 25 – 26, respectively. The transverse section of the leaf through the midrib suggests that the vascular bundles are conjoint, collateral and closed. Moisture content, total ash, acid insoluble ash, water soluble ash, sulphated ash, water soluble and alcohol soluble extractives were as follows; 7.7 ± 1,5, 4.9 ± 0.7, 1.2 ± 0.8, 4.1 ± 0.2, 4.8 ± 0.9, 3.9 ± 0.9, 8.1 ± 1.7w/w%, respectively. Peptidomic analysis revealed the abundant expression of nature-derived knottin-like peptides with a mass range of 3.1 kDa – 3.7 kDa. Knottin peptides have been reported to perform defense roles in host plants; since they are not ubiquitously distributed in planta, their detection in RVM could be useful in the proper identification of the plant and in RVM chemosystematics. Findings from this study has unveiled some important macroscopic, microscopic and physicochemical standards as well as a new peptidomic phytochemical standard helpful in the proper identification in addition to ensuring the efficacy and safety of the leaf of R. vomitoria.
“…Because the roots, leaves, shoots, and flowers contain high concentrations of secondary metabolites, they are widely used in traditional medicines. This species has been used historically in India, Myanmar, Bangladesh, Nepal, and other countries in the wider region (Bhagat et al 1980;Dey and De 2011;Ei et al 2017;Surendran et al 2021). This evergreen shrub species thrives on moist forest floors and has a low regeneration rate, owing to the production of many non-viable seeds.…”
Non-timber forest products (NTFPs) are essential for rural livelihoods but are often threatened by deforestation and overexploitation. Rauvolfia serpentina is a critical NTFP species; however, there have been no studies on the impact of future climate change on its potential habitat distribution. We used the Maxent modeling approach to address this knowledge gap and determine this species current and future suitability under climate change scenarios. The areas more suitable to its occurrence were mainly located near the southwestern coastal regions of Myanmar and India. Based on our predictions, these very high suitability areas are likely to decrease in 2070 under both low and high CO 2 emission scenarios, indicating the future vulnerability of this species habitat to the impact of climate change. This species is a highly valued NTFP species in the study region; therefore, such a reduction in habitat suitability may result in reductions in NTFP production and economic benefits for the dependent populations. Our findings can help define and conserve areas containing the natural habitats of this high-valued NTFP species.
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