A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of the genus Dorema

Mottaghipisheh, Javad; Vitalini, Sara; Pezzani, Raffaele

doi:10.1007/s11101-020-09727-z

Cited by 6 publications

(1 citation statement)

References 39 publications

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“…Семейство также занимает центральное место в обширных исследованиях по оцифровке гербарных образцов. Род Dorema Don, считается одним из небольших родов семейства, распространено от Кавказа и Ирана до Белуджистана [9]. В фонде TASH хранится 97 экземпляров гербарных образцов, относящихся к 7 родам Dorema.…”

Section: Introductionunclassified

Analysis of Herbar Specimens of the Genus Dorema Don (Apiaceae Lindl.), Kept in the National Herbarium of Uzbekistan (Tash).

Мирзаолимова,

Абдуллаев,

Батошов

2023

SJFSU

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Наманганский государственный университет базовые докторанты кафедры биологии 2 Абдуллаев Шухратжон Солижанович 1 -Наманганский государственный университет базовые докторанты кафедры биологии 3 Батошов Авазбек Рискулович -Наманганский государственный университет доктор биологических наук, доцент Annotatsiya Ushbu maqolada Oʻzbekiston Milliy gerbariysida (TASH) saqlanayotgan Dorema Don turkumiga mansub 97 ta gerbariy namunalari tahlil qilingan. Natijada TASH fondida Dorema turkumiga mansub 7 turning namunalari saqlaniyotgani aniqlangan hamda turlarning yig'ish yillari, kollektorlari, geografik tarqalishi tahlil qilingan. O'zbekiston florasida mavjud D. microcarpum va D. sabulosum turlarining tarqalishining GAT xaritalari aks ettirilgan. Аннотация В статье проанализировано 97 гербарных образцов, относящийся роду Dorema Don, хранящихся в Национальном гербарии Узбекистана (TASH). В результате данной работы установлено, что в фонде TASH хранятся экземпляры 7 видов, принадлежащих к роду Dorema, а также проанализированы годы сбора, коллекторы и географическое распространение видов. Представлены GAT карты распространения видов D. microcarpum и D. sabulosum, встречающих во флоре Узбекистана.

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Section: Introductionunclassified

Analysis of Herbar Specimens of the Genus Dorema Don (Apiaceae Lindl.), Kept in the National Herbarium of Uzbekistan (Tash).

Мирзаолимова,

Абдуллаев,

Батошов

2023

SJFSU

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Separation and evaluation of potential antioxidant, analgesic, and anti-inflammatory activities of limonene-rich essential oils from Citrus sinensis (L.)

et al. 2022

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The peel of Citrus sinensis (L.) Osbeck is a source of essential oils, particularly limonene, which is this plant’s characteristic molecule. The main goal of this study was to test the potential analgesic and anti-inflammatory properties of limonene-rich essential oils derived from the peel of C. sinensis L. (orange) in vivo, as well as their antioxidant activity in vitro. Carrageenan-induced paw edema in Wistar rats and the formalin test in Swiss albino mice were used to examine anti-inflammatory activity. The analgesic activity was assessed using hot plate and acetic acid writhing tests, while the antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl and ferric reducing antioxidant power methods. The essential oil (EO) safety was determined using an acute toxicity experiment on mice. The phytochemical analysis confirmed the existence of limonene as the primary molecule (88.94%), and in vivo experiments revealed that the EO had a significant pain and inflammation-relieving effect, especially at the dose of 50 mg/kg, when compared to the used control drugs. The acute toxicity evaluation reported this EO’s safety. This study contributes to the pharmacological valorization of the peel of C. sinensis L., confirming that, in addition to its numerous cosmetic and industrial uses, it may be effective in the treatment of inflammatory and pain-related illnesses.

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Investigating the Effects of Dorema hyrcanum Root Extracts on Selective Induction of Programmed Cell Death in Glioblastoma, Ovarian Cancer and Breast Cancer Cell Lines

Shandi,

Sahranavard,

Bagheri

et al. 2024

ACAMC

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Background: Despite remarkable advances, cancer has remained the second cause of death, which shows that more potent novel compounds should be found. Ethnobotanical compounds have a long history of treating diseases, and several approved chemotherapeutic compounds were isolated from plants. background: Despite remarkable advances, cancer has remained the second cause of death which shows that more potent novel compounds should be found. Ethnobotanical compounds have a long history in treatments of diseases and several approved chemotherapeutic compounds were isolated from plants. Objective: The research aimed to evaluate the cytotoxic effects of Dorema hyrcanum root extract on ovarian, breast, and glioblastoma cells while examining its selectivity towards normal cells. Additionally, the study is directed to investigate cell death mechanisms, delineate modes of cell death, and explore intracellular ROS production. objective: investigating the cytotoxic impacts of Dorema Hyrcanum on basal-like triple negative breast cancer, cis-platin-resistant ovarian cancer, and glioblastoma cells. Methods: Cytotoxic effects of alcoholic, dichloromethane, and petroleum ether fractions of Dorema hyrcanum were investigated on cancer and normal cells by using MTT assay, and the concentration around IC50 values was used for flow cytometric assessment of apoptosis, evaluation of the expression of selected genes via RT-qPCR and production of ROS. Results: Methanolic extract exhibited the highest cytotoxicity, impacting A2780CP and MDA-MB-231. All fractions showed comparable effects on U251 cells. Notably, extracts displayed higher IC50 values in normal HDF cells, indicating cancer cell specificity. Flow cytometry revealed induction of apoptosis and non-apoptotic death in all three cancer cell lines. QPCR results showed upregulation of related genes, with RIP3K prominently increased in U251 glioblastoma. The DCFH-DA assay demonstrated ROS induction by the PE fraction exclusively in A2780CP cells after 30 minutes and up to 24 hours. result: The IC50 values showed that these fractions significantly induced cell death in values very lower than toxic doses in normal fibroblasts. The impact of different fractions on the induction of apoptosis and the results of gene expression profiles demonstrated that fractions induce cell death discreetly in different cell lines accompanied by induction of ROS production in specific fractions. Conclusion: Dorema hyrcanum root extracts exhibited potent anti-tumor effects against all studied cell lines. The methanolic extract demonstrated the highest cytotoxicity, particularly against A2780CP and MDA-MB-231 cells. Importantly, all fractions displayed selectivity for cancer cells over normal HDF cells. Unique modes of action were observed, with the petroleum ether fraction inducing significant non-apoptotic cell death. These findings suggest promising therapeutic potential for Dorema hyrcanum in cancer treatment with subject to further mechanistic studies.

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A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of the genus Dorema

Cited by 6 publications

References 39 publications

Analysis of Herbar Specimens of the Genus Dorema Don (Apiaceae Lindl.), Kept in the National Herbarium of Uzbekistan (Tash).

Analysis of Herbar Specimens of the Genus Dorema Don (Apiaceae Lindl.), Kept in the National Herbarium of Uzbekistan (Tash).

Separation and evaluation of potential antioxidant, analgesic, and anti-inflammatory activities of limonene-rich essential oils from Citrus sinensis (L.)

Investigating the Effects of Dorema hyrcanum Root Extracts on Selective Induction of Programmed Cell Death in Glioblastoma, Ovarian Cancer and Breast Cancer Cell Lines

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