A comprehensive review of various biopolymer composites and their applications: From biocompatibility to self-healing

Kumar, Abhideep; Mishra, Raghvendra Kumar; Verma, Kartikey; Aldosari, Salem Mohammed; Maity, Chandan; Verma, Subhash; Patel, Rajat; Thakur, Vijay Kumar

doi:10.1016/j.mtsust.2023.100431

Cited by 17 publications

(4 citation statements)

References 99 publications

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“…[64] Grafting monomers onto the foundational biopolymers has been accomplished through a range of techniques, encompassing chemical and ionic methods, as well as approaches induced by gamma-irradiation or enzymes. [65,66] These innovative modification methods enhance the versatility of biomaterials, allowing for the creation of tailored structures with enhanced properties, thereby expanding their potential applications in various fields, including drug delivery and tissue engineering. Many advantages have been reported for using smart delivery systems including releasing the drug in a programmed manner with improved efficiency, minimizing the administration times, the dose, and providing a short drug half-life, which will reduce the potentially harmful side effects, especially for anticancer drugs.…”

Section: Controlled Drug Releasementioning

confidence: 99%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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Cancer stands as a leading cause of global mortality, with chemotherapy being a pivotal treatment approach, either alone or in conjunction with other therapies. The primary goal these therapies is to inhibit the growth of cancer cells specifically, while minimizing harm to healthy dividing cells. Conventional treatments have been hampered by their side effects, often causing severe discomfort to patients. Researchers have been exploring innovative approaches to target cancer cells selectively. In this context, biopolymer‐based aerogels emerge as innovative platforms, showcasing unique properties that respond intelligently to diverse stimuli, including temperature, pH variations, magnetic fields, and redox potential. This responsiveness enables precise control over the release of anticancer drugs, enhancing therapeutic outcomes. The significance of these aerogels lies in their ability to offer targeted drug delivery with increased efficacy, biocompatibility, and a high drug payload. In this comprehensive review, we discuss the role of biopolymer‐based aerogels as an emerging functionalized platforms in anticancer drug delivery. The review addresses the unique properties of biopolymer‐based aerogels showing their smart behavior in responding to different stimuli including temperature, pH, magnetic and redox potential to control anticancer drug release. Finally, the review discusses the application of different biopolymer‐based aerogel in delivering different anticancer drugs and also discusses the potential of these platforms in gene delivery applications. This article is protected by copyright. All rights reserved

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Section: Controlled Drug Releasementioning

confidence: 99%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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“…In recent years, significant progress has been made in developing high-performance hemicellulose-based films. Hemicelluloses, as natural biopolymers, have garnered considerable attention in the domain of environmental materials owing to their exemplary biodegradability [ 90 ], which is capable of rapid decomposition under natural conditions, significantly mitigating the environmental impacts when juxtaposed with traditional plastics [ 91 ]. However, due to the structural properties of hemicellulose, there are challenges in its compatibility with traditional plastics, as well as in the thermal stability, mechanical properties, and water vapor permeability of hemicellulose materials [ 81 ].…”

Section: Applications Of Gobp Hemicellulosementioning

confidence: 99%

Valorization of Grain and Oil By-Products with Special Focus on Hemicellulose Modification

Liu,

Xie,

Jacquet

et al. 2024

Polymers

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Hemicellulose is one of the most important natural polysaccharides in nature. Hemicellulose from different sources varies in chemical composition and structure, which in turn affects the modification effects and industrial applications. Grain and oil by-products (GOBPs) are important raw materials for hemicellulose. This article reviews the modification methods of hemicellulose in GOBPs. The effects of chemical and physical modification methods on the properties of GOBP hemicellulose biomaterials are evaluated. The potential applications of modified GOBP hemicellulose are discussed, including its use in film production, hydrogel formation, three-dimensional (3D) printing materials, and adsorbents for environmental remediation. The limitations and future recommendations are also proposed to provide theoretical foundations and technical support for the efficient utilization of these by-products.

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“…Developing new biodegradable and eco-friendly polymer films has been regarded as a very promising route to solve the worsening problem of “white pollution”. , Derived from renewable resources, polylactide (PLA) has been regarded as one of the most competitive biobased substituents to traditional petroleum-based polymers owing to its attractive biodegradability, mechanical strength, and processability. − Unfortunately, the inherent brittleness and inferior heat resistance have become the predicaments that restrict the utilization scope of PLA, as evidenced by the insufficient ductility with only about 5% of elongation at break − as well as low heat deflection temperatures (HDT, only ∼50–60 °C). , Therefore, enormous efforts have been made to endow PLA films with satisfactory mechanical properties and excellent heat resistance for the expansion of their applications.…”

Section: Introductionmentioning

confidence: 99%

Integration of Stiffness, Ductility, Heat Resistance, and Transparency for Polylactide Films by Manipulation of Amorphous Chain Networks and Oriented Nanocrystals

Wei,

Huang,

Jia

et al. 2024

Macromolecules

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Developing a promising and scalable strategy for simultaneously improving ductility, stiffness, heat resistance, as well as transparency of polylactide (PLA) films is of great significance but remains a big challenge. In this work, the manipulation of the amorphous chain network and oriented nanocrystals simultaneously reconciles mechanical properties, heat resistance, and transparency of isotropic PLA films via the "biaxial orientation-confined crystallization" process. The biaxial extensional stress with a high strain rate induces the oriented homocrystallites (HCs), which can act as physical cross-links, and strengthens the amorphous chain entanglement network. Subsequent confined crystallization is utilized to promote the perfection of oriented HCs and simultaneously induce the formation of stereocomplex crystals (SCs), further strengthening the chain entanglement and restricting chain relaxation. Thus, superior stiffness−ductility balance is achieved as the elongation at break and yield strength increase from 12.5% and 56.2 MPa to 106.1% and 84.2 MPa, respectively. Moreover, the newly formed oriented SCs also impart excellent heat resistance, with a remaining storage modulus of 11.5 MPa at 190 °C and a certain dimensional stability in the hot oil (170 °C). Furthermore, the nanocrystals also impart PLA films with good transparency (>90% at 550 nm). This work could provide significant guidance for the facile and efficient fabrication of high-performance PLA films, promoting sustainable development in polymer film manufacturing.

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A comprehensive review of various biopolymer composites and their applications: From biocompatibility to self-healing

Cited by 17 publications

References 99 publications

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Valorization of Grain and Oil By-Products with Special Focus on Hemicellulose Modification

Integration of Stiffness, Ductility, Heat Resistance, and Transparency for Polylactide Films by Manipulation of Amorphous Chain Networks and Oriented Nanocrystals

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