A comprehensive review of the application of probiotics and postbiotics in oral health

Rad, Aziz Homayouni; Pourjafar, Hadi; Mirzakhani, Esmaeel

doi:10.3389/fcimb.2023.1120995

Cited by 51 publications

(38 citation statements)

References 242 publications

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“…The results demonstrated all the tested LAB have a positive effect in the containment of pathogen growth but only some of them induce a substantial reduction in this parameter; furthermore, the preventive model activity resulted more effective than the treatment assay. As highlighted by a recent review, probiotic bacteria may stimulate an immune response against pathogens, inhibiting the growth of bacteria that cause dental cavities and periodontal diseases, and preventing inflammation and damage to tissue in the oral cavity [44].…”

Section: Discussionmentioning

confidence: 99%

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains Against Oral Pathogens

Squarzanti,

Dell'Atti,

Scalia

et al. 2024

Preprint

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The microbiota in the oral cavity has a strict connection to its host. Its unbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains (Lactobacillus acidophilus PBS066, Lactobacillus crispatus LCR030, Lactobacillus gasseri LG050, Lactiplantibacillus plantarum PBS067, Limosilactobacillus reuteri PBS072, Lacticaseibacillus rhamnosus LRH020, Bifidobacterium animalis subsp. lactis BL050, Lacticaseibacillus paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114) against two main oral pathogens, Streptococcus mutans and Aggregatibacter actinomycetemcomitans, involved in dental caries and periodontal disease development and progression. Our results, obtained through agar overlay assay, plate count method, and scanning electron microscope imaging, indicate that the tested probiotics prevent the growth and adhesion of oral pathogens in a strain-specific manner, improving oral health. L. plantarum PBS067, L. rhamnosus LRH020, L. paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114 performed in a significant way against both pathogens in all the tests used. They can be considered as an effective adjuvant to guarantee oral and systemic well-being.

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Section: Discussionmentioning

confidence: 99%

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains Against Oral Pathogens

Squarzanti,

Dell'Atti,

Scalia

et al. 2024

Preprint

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“…Orthodontic patients may benefit from probiotics to prevent the development of white spot problems brought on by tooth enamel decalcification. In particular, Streptococcus mutans , recognized as the main cause of dental caries, is more prevalent in the plaque of people receiving orthodontic therapy than in the plaque of people not receiving it [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Three Probiotics for Streptococcus mutans Prevention in Plaque Around Orthodontic Braces

Baxi¹,

Bhatia²,

Tripathi³

et al. 2023

Cureus

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Background and aim: Orthodontic brackets can be a significant factor in enamel demineralization due to their complex structure, which makes brushing the teeth difficult and promotes the accumulation of food particles and dental plaque. The fact that metal braces have the highest surface tension and are more likely to cause enamel demineralization, which can result in the development of white spot lesions and enamel caries, is of critical significance to doctors, dentists, and patients. Probiotics have a beneficial effect in preventing and treating oral infectious diseases like tooth decay, gingival disorders, and bad breath. Research has shown that taking probiotics lowers the amount of Streptococcus mutans in the body. There has not been much research done to examine the results of administering a probiotic medication locally. This study was conducted to examine the effectiveness of three separate probiotics in the prevention of S. mutans accumulation in plaque surrounding orthodontic braces. Materials and methods: A randomized controlled trial was conducted. The volunteers for each group were chosen using a straightforward random method. The sample size was 160 empirically determined subjects. They were divided as follows: study group 1 received probiotic lozenges (n=40). Study group 2 received probiotic sachets (n=40). Study group 3 received probiotic beverages (n=40). Group 4 was the control group, those who did not get probiotics (n=40). The samples were then plated onto culture media to test for Streptococcus mutans . S. mutans colonies were counted using a computerized colony counter. Results: The mean values of colony forming units (CFU/mL) of S. mutans at baseline in the control group were 354±23.6, while they were 232±41.7 at the end of the observation duration. The difference was non-relevant statistically (p=0.793). The mean values of CFU/mL of S. mutans at baseline in the group taking probiotic lozenges were 358.7±39.93, while they were 57±10.12 at the end of the observation duration. The difference was relevant statistically (p=0.021). The mean values of CFU/mL of S. mutans at baseline in the group taking probiotic sachets were 321.36±41.67, while they were 215.5±22.66 at the end of the observation duration. The difference was relevant statistically (p=0.043). The mean values of CFU/mL of S. mutans at baseline in the group taking the probiotic drink were 335.76±40.12, while they were 75.1±28.74 at the end of the observation duration. The difference was relevant statistically (p=0.032). Conclusion: There was a significant decline in the number of colonies of S. mutans in all three forms of probiotics; however, the decline was greatest in the study participants taking probiotic lozenges.

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“…Data from randomized clinical trials also suggest that probiotics influence caries development, especially with supplemented milk or reconstituted milk powder. This influence may be attributed to modifications in biofilm/saliva metabolic and/or immunologic processes, including but not limited to, reduced extracellular matrixrelated enzymatic activity, increased salivary buffering capacity, and enhanced production of defense factors such as IgA or HNP1 [16,17].…”

Section: Introductionmentioning

confidence: 99%

Probiotics‐containing beverages and dental caries: A systematic review and meta‐analysis

Feldmann,

Eidt,

Henz

et al. 2024

European J Oral Sciences

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The aim was to evaluate the effect of probiotics‐containing beverages on dental caries development by a systematic review and meta‐analysis (PROSPERO CRD42021258010). PubMed, Embase, and Web of Science databases were assessed (up to October 2023) for randomized placebo‐controlled trials that evaluated the consumption of probiotics‐containing beverages having dental caries as endpoint. Risk of bias assessment (Cochrane Handbook) was performed for all studies. Risk ratio (RR), standardized mean difference (SMD) and 95% confidence interval (CI), were calculated for caries prevalence and caries increment, respectively. Meta‐analysis was performed. Qualitative analysis of more than 2000 individuals aged from 1 to 84 years (9 studies) showed inconsistent effects of these probiotics‐containing beverages. Synthesis of more than 1000 children and adolescents did not demonstrate a statistically significant difference in the proportion of individuals with cavitated lesions (RR 0.60 [95 % CI 0.34 to 1.08]; n = 2), but a significantly smaller increment of both cavitated and non‐cavitated carious lesions (SMD −0.23 [95 % CI −0.39 to −0.08]; n = 4) was related to the consumption of probiotics‐containing beverages. Certainty of evidence for caries prevalence and caries increment were moderate and low, respectively. Current evidence is not substantial to strengthen the impact of these beverages on caries development.

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A comprehensive review of the application of probiotics and postbiotics in oral health

Cited by 51 publications

References 242 publications

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains Against Oral Pathogens

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains Against Oral Pathogens

Comparative Evaluation of Three Probiotics for Streptococcus mutans Prevention in Plaque Around Orthodontic Braces

Probiotics‐containing beverages and dental caries: A systematic review and meta‐analysis

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