Sex-related differences in physiology and anatomy are responsible for
profound differences in neuromuscular performance and fatigability between men
and women. Women are usually less fatigable than men for similar intensity
isometric fatiguing contractions. This sex difference in fatigability, however,
is task specific because different neuromuscular sites will be stressed when the
requirements of the task are altered, and the stress on these sites can differ
for men and women. Task variables that can alter the sex difference in fatigue
include the type, intensity and speed of contraction, the muscle group assessed,
and the environmental conditions. Physiological mechanisms that are responsible
for sex-based differences in fatigability may include activation of the motor
neuron pool from cortical and subcortical regions, synaptic inputs to the motor
neuron pool via activation of metabolically-sensitive small afferent fibres in
the muscle, muscle perfusion, and skeletal muscle metabolism and fibre type
properties. Non-physiological factors such as the sex bias of studying more
males than females in human and animal experiments can also mask a true
understanding of the magnitude and mechanisms of sex-based differences in
physiology and fatigability. Despite recent developments, there is a tremendous
lack of understanding of sex differences in neuromuscular function and
fatigability, the prevailing mechanisms and the functional consequences. This
review emphasises the need to understand sex-based differences in fatigability
in order to shed light on the benefits and limitations that fatigability can
exert for men and women during daily tasks, exercise performance, training and
rehabilitation in both health and disease.