A comprehensive review of the Direct Peptide Reactivity Assay in skin sensitization testing: Applicability, limitations, and considerations
Elma Omeragić,
Belma Imamović,
Mirza Dedić
et al.
Abstract:Skin sensitization is a crucial endpoint in the safety assessment of chemicals, with the Direct Peptide Reactivity Assay (DPRA) emerging as a valuable in chemico method for evaluating a substance's sensitization potential. This review delves into the principles, applicability, and limitations of the DPRA within the context of the Adverse Outcome Pathway (AOP) framework for skin sensitization. We examine the DPRA'srole in addressing the molecular initiating event of skin sensitization, its integration into Inte… Show more
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