A comprehensive review of recent advances in the biological activities of quinazolines

Abstract

Quinazoline heterocycles are critical in the development of medications.Quinazoline derivatives have been intensively researched, providing a wide range of compounds with diverse biological roles. The quinazoline nucleus has garnered a lot of attention in medical chemistry in recent years. It was assumed to be a pharmacophore component in the development of physiologically interesting drugs. This review is an attempt to increase the potential of quinazoline by highlighting a wide range of advancements demonstrated by numerous derivatives of the quinazoline moiety, as well as focusing on diverse pharmacological actions of the quinazoline moiety. This review compiles recent studies on the quinazoline moiety described in the literature by researchers.

Microwave Synthesized Hydrophilic 4‐Oxo‐2‐phenylquinazoline‐3(4H)–carboximidamide and –Carboxamide as Privileged Small Molecule Scaffolds with Anti‐HIV‐1 Activities

“…These heterocycles are essential constituents of natural systems and are frequently found in alkaloids and many bioactive molecules [10] . The unique structure of quinazolines with two fused six‐membered aromatic rings, benzene, and a pyrimidine ring, impart to it interesting properties that can be exploited in biological systems [11–14] . The presence of the benzene ring enhances the reactivity of the 3,4‐double bond, making quinazolines very reactive to incoming nucleophiles.…”

“…[10] The unique structure of quinazolines with two fused six-membered aromatic rings, benzene, and a pyrimidine ring, impart to it interesting properties that can be exploited in biological systems. [11][12][13][14] The presence of the benzene ring enhances the reactivity of the 3,4-double bond, making quinazolines very reactive to incoming nucleophiles. They have a wide range of versatile applications that include a plethora of biological activities like anti-cancer, anti-inflammatory, antiviral, antibiotics, and many other medicinal applications.…”

Regioselective quinazoline C2 modifications through the azide–tetrazole tautomeric equilibrium

“…The commercially available 2,4-dichloro-6,7-dimethoxyquinazoline ( 7 ) was chosen for this purpose ( Scheme 3 ). The common dimethoxy motif is also found in a variety of quinazoline-based pharmaceuticals [ 2 – 3 8 , 23 ].…”

“…The quinazoline core is a privileged structure with a wide range of applications. Quinazoline derivatives exhibit a broad spectrum of biological activities, finding use as anticancer, antimicrobial, antimalarial, and antiviral agents [1,2]. Furthermore, numerous 2-amino-6,7-dimethoxyquinazoline analogs are extensively employed as α 1 -adrenoceptor blockers [3,4].…”

Tannic acid-poly ethyleneimine magnetic nanoparticles: an efficient and recyclable catalyst for green synthesis of 2,3-dihydroquinazole derivatives

“…Quinazoline heterocycles are an important group of nitrogen-containing cyclic compounds. These heterocycles are vital in the development of pharmaceuticals and provide a variety of biologically active scaffolds [97][98] . It has been reported that quinazoline derivatives have various biological and therapeutic properties including antibacterial, anti-in ammatory, antifungul, anticancer, anti-plasmodial, anti-tumor, antimicrobial and antioxidant ability [99][100][101] .…”