A comprehensive review of recent advances in silk sericin: Extraction approaches, structure, biochemical characterization, and biomedical applications

Saad, Massoud A. H.; El-Samad, Lamia M.; Gomaa, Rehab A.; Augustyniak, Maria; Hassan, Mohamed A.

doi:10.1016/j.ijbiomac.2023.126067

Cited by 26 publications

(10 citation statements)

References 236 publications

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“…Prakash et al [182] reported in detail on composites using regenerated silk fibroin loaded with natural additives. Saad et al [183] examined the sericin biomedical and pharmaceutical applications regarding nanomaterials. Other important biomedical applications of silk fiber or its fibrous derivatives include bone formation by fiber-reinforced calcium phosphate cement [184], formation of highstrength hydrogels [185], tissues for repairing the injured nervous system [186], hard tissue engineering [187], etc.…”

Section: Animal and Mineral Fibers And Nanocompositesmentioning

confidence: 99%

Natural Fibers Composites: Origin, Importance, Consumption Pattern, and Challenges

Thapliyal,

Verma,

Sen

et al. 2023

J. Compos. Sci.

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This comprehensive review explores the multifaceted world of natural fiber applications within the domain of composite materials. Natural fibers are meticulously examined in detail, considering their diverse origins, which encompass plant-derived fibers (cellulose-based), animal-derived fibers (protein-based), and even mineral-derived variations. This review conducts a profound analysis, not only scrutinizing their chemical compositions, intricate structures, and inherent physical properties but also highlighting their wide-ranging applications across various industries. The investigation extends to composites utilizing mineral or polymer matrices, delving into their synergistic interplay and the resulting material properties. Furthermore, this review does not limit itself to the intrinsic attributes of natural fibers but ventures into the realm of innovative enhancements. The exploration encompasses the augmentation of composites through the integration of natural fibers, including the incorporation of nano-fillers, offering a compelling avenue for further research and technological development. In conclusion, this review synthesizes a comprehensive understanding of the pivotal role of natural fibers in the realm of composite materials. It brings together insights from their diverse origins, intrinsic properties, and practical applications across sectors. As the final curtain is drawn, the discourse transcends the present to outline the trajectories of future work in the dynamic arena of natural fiber composites, shedding light on emerging trends that promise to shape the course of scientific and industrial advancements.

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Section: Animal and Mineral Fibers And Nanocompositesmentioning

confidence: 99%

Natural Fibers Composites: Origin, Importance, Consumption Pattern, and Challenges

Thapliyal,

Verma,

Sen

et al. 2023

J. Compos. Sci.

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“…A majority of current reviews emphasize on the development of silk sericin-based biomaterials used in drug delivery and tissue engineering, , and in food and pharmaceutical industries, , etc. However, few reviews elaborate on the fundamental properties of sericin as well as other aspects of this compound such as extraction routes, possible chemical modifications, various blends, etc.…”

Section: Introductionmentioning

confidence: 99%

Waste to Wealth: Exploring the Versatile Prospects of Discarded Silk Sericin

Sabu Mathew,

Maria,

Allardyce

et al. 2024

ACS Sustainable Chem. Eng.

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Biorefinery, the process of converting biomass to valueadded materials, is gaining significant interest because of the depletion of natural resources and an increasing awareness of the need for sustainable development and material production. Silk sericin, an abundantly available byproduct of the sericulture industry, has been identified for biorefinery usage since it is biodegradable, bioavailable, pH and temperatureresponsive, naturally photoluminescent, has antioxidant properties, and is a GRAS and FDA-safe food additive. This Perspective examines the properties of sericin and its sources and discusses currently explored applications, including as a delivery system for drugs or genetic material, for wound healing, tissue engineering, media supplements, cosmetology, packaging materials, edible coating, and as bio adhesives. This Perspective examines the sources of sericin, its properties, and some of the currently explored applications. These include biomedical applications such as a delivery system for drugs or genetic material, wound healing, tissue engineering, media supplements, cosmetology, packaging materials, edible coating, and as bio adhesives. Finally, we highlight the recent developments in sericin modification to functionalize it for specific applications; this is a promising future direction that will further enhance the potential use of this valuable biomass.

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“…Structurally, silk comprises the inner core of fibroin (70-80%) and the outer layer of sericin (20-30%) along with other substances such as waxes and pigments [3]. Due to the favorable antioxidant properties, antibacterial properties, UV protection, excellent water solubility, and moisture retention [4], sericin has been used to prepare silk sericin-based biomaterials (SS-based biomaterials) by cross-linking, copolymerization, and combining with other polymers [5]. The forms of silk sericin-based biomaterials include nanoparticles, hydrogel, scaffolds, films, and microneedles [6].…”

Section: Introductionmentioning

confidence: 99%

“…Differences in the type and content of carotenoids in silkworm silk glands are responsible for the coloration of cocoons. In previous research, the raw material for sericin used was derived from white cocoons, while no reports on the use of sericin from naturally colored cocoon resources were noted [4,16].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Natural Carotenoids-Containing Sericin of the Domestic Silkworm Bombyx mori

Liu,

Zhang,

Zhou

et al. 2024

IJMS

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Sericin derived from the white cocoon of Bombyx mori has been attracting more attention for its utilization in food, cosmetics, and biomedicine. The potential health benefits of natural carotenoids for humans have also been well-established. Some rare strains of Bombyx mori (B. mori) produce yellow–red cocoons, which endow a potential of natural carotenoid-containing sericin. We hypothesized that natural carotenoid-containing sericin from yellow–red cocoons would exhibit better properties compared with white cocoon sericin. To investigate the physicochemical attributes of natural carotenoid-containing sericin, we bred two silkworm strains from one common ancestor, namely XS7 and XS8, which exhibited different cocoon colors as a result of the inconsistent distribution of lutein and β-carotene. Compared with white cocoon sericin, the interaction between carotenoids and sericin molecules in carotenoid-containing sericin resulted in a unique fluorescence emission at 530, 564 nm. The incorporation of carotenoids enhanced the antibacterial effect, anti-cancer ability, cytocompatibility, and antioxidant of sericin, suggesting potential wide-ranging applications of natural carotenoid-containing sericin as a biomass material. We also found differences in fluorescence characteristics, antimicrobial effects, anti-cancer ability, and antioxidants between XS7 and XS8 sericin. Our work for the first time suggested a better application potential of natural carotenoid-containing sericin as a biomass material than frequently used white cocoon sericin.

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A comprehensive review of recent advances in silk sericin: Extraction approaches, structure, biochemical characterization, and biomedical applications

Cited by 26 publications

References 236 publications

Natural Fibers Composites: Origin, Importance, Consumption Pattern, and Challenges

Natural Fibers Composites: Origin, Importance, Consumption Pattern, and Challenges

Waste to Wealth: Exploring the Versatile Prospects of Discarded Silk Sericin

The Potential of Natural Carotenoids-Containing Sericin of the Domestic Silkworm Bombyx mori

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