A Comprehensive Review of Neuromuscular Manifestations of COVID-19 and Management of Pre-Existing Neuromuscular Disorders in Children

Goetschius, Daniel J.; Kumar, Ashutosh; Paul, Dustin; Naik, Sunil

doi:10.3390/jcm11040934

Cited by 4 publications

(5 citation statements)

References 71 publications

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“…These assessments, tools, and adaptations should be patient-centric and customized according to factors like disease severity [ 35 , 43 ], comorbidities [ 34 , 49 ], patient age [ 9 , 44 , 48 , 50 ], access to the internet [ 43 , 44 ], and the coadministration of drugs like corticosteroids that are necessary but lower immunity [ 29 , 34 , 36 ]. Additionally, strategies like use of prioritized assessments and protocol flexibility (both encouraged by the FDA during the pandemic) may help ensure trial continuity [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…During the pandemic, SMA community members had to balance concerns about COVID-19 exposure with the need to access key healthcare services for management of SMA, such as treatment administration and monitoring, physical therapy, and in-home care [ 29 – 31 ]. While telehealth visits can support continuity of care in some settings, many SMA-related services—such as diagnosis confirmation, drug administration, and physical therapy—still require in-person interaction [ 29 , 32 – 36 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of the COVID-19 Pandemic on SMA Screening and Care: Physician and Community Insights

Curry

Peterson²,

Belter

et al. 2023

Neurol Ther

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Objective As part of efforts to reduce diagnostic delays and enhance clinical trials, Cure SMA evaluated the effects of COVID-19 on SMA care and clinical trial conduct. Introduction Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by progressive, potentially debilitating muscle weakness and atrophy. Uninterrupted access to early diagnosis, disease-modifying treatment, and care for SMA is vital to avoiding irreversible motor neuron death and achieving optimal patient outcomes. Methods Two surveys were conducted: a provider survey and a community survey. The Provider Impact Survey, distributed from November 24, 2020, through March 8, 2021, assessed COVID-19’s effects on referrals for evaluation of suspected SMA, cancellations and delays of SMA-related care, and clinical trials. The Community Impact Survey was fielded in three waves between April 7, 2020 and July 19, 2021, in tandem with Cure SMA COVID-19 support programs. Results A total of 48 completed provider surveys (22 from care sites, 26 from care-and-trial sites) reflected decreases in referrals for suspected SMA, increases in appointment cancellations and delays, and patient reluctance to attend in-person visits due to COVID-19. One-third of care-and-trial sites reported trial recruitment delays, and one-quarter reported pausing trial enrollment. Results of the Community Impact Survey, completed by 2047 individuals, showed similar disruptions, with 55% reporting changes or limitations in accessing essential SMA-related services. Conclusions This research evaluates the pandemic’s interruption of SMA care and research. These insights can help mitigate and increase preparedness for future disruptive events. Expanded use of virtual tools including telehealth and remote monitoring may enhance continuity and access. However, additional research is required to evaluate their effectiveness. While this research was specific to SMA, its findings may have relevance for other patient communities. Supplementary Information The online version contains supplementary material available at 10.1007/s40120-023-00516-2.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of the COVID-19 Pandemic on SMA Screening and Care: Physician and Community Insights

Curry

Peterson²,

Belter

et al. 2023

Neurol Ther

View full text Add to dashboard Cite

show abstract

“…On the other hand, it has been reported that COVID-19 disease might lead to neurological impairment by damaging the central and peripheric nervous system through dysregulated inflammatory stimuli, hypoxia, and direct lesion mechanisms [22]. More in detail, COVID-19 neuromuscular sequelae might be directly or indirectly connected to SARS-CoV-2 infection; hence, a COVID-19 affinity for neural tissue has been proposed, with the direct infection and injury of motor neurons and peripheral nerves reported two to three weeks after infection [23,24]. In accordance, a third of patients with other coronavirus infections complained of myalgia, high creatine kinase (CK) levels, and rhabdomyolysis, suggesting that the infection may induce viral myositis [23,24].…”

Section: Organic and Functional Impact Of Covid-19 On Anterior Crucia...mentioning

confidence: 99%

“…More in detail, COVID-19 neuromuscular sequelae might be directly or indirectly connected to SARS-CoV-2 infection; hence, a COVID-19 affinity for neural tissue has been proposed, with the direct infection and injury of motor neurons and peripheral nerves reported two to three weeks after infection [23,24]. In accordance, a third of patients with other coronavirus infections complained of myalgia, high creatine kinase (CK) levels, and rhabdomyolysis, suggesting that the infection may induce viral myositis [23,24]. Moreover, high levels of LDH were found in subjects with myalgia and fatigue, and elevated levels of myoglobin were documented in severe COVID-19 [25].…”

Section: Organic and Functional Impact Of Covid-19 On Anterior Crucia...mentioning

confidence: 99%

“…Whether the increment of CK levels and myopathic damage might be induced by toxic developments of cytokines patterns, the viral infection of the muscle itself, or other unknown mechanisms is still unclear [26]. Nonetheless, data from muscle biopsies suggested crucial pathophysiologic accountability of severe immune activation typically featured in COVID-19 patients [23,24].…”

Section: Organic and Functional Impact Of Covid-19 On Anterior Crucia...mentioning

confidence: 99%

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Impact of COVID-19 Era on the Anterior Cruciate Ligament Injury Rehabilitation: A Scoping Review

Marotta,

de Sire,

Calafiore

et al. 2023

JCM

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The surgical intervention rate and the subsequent rehabilitation plan for anterior cruciate ligament (ACL) injury was crucially affected by the COVID-19 pandemic due to the necessity in the face of the emergency. This review aimed to evaluate potential persistent and residual symptoms after COVID-19 disease, including fatigue and neuromuscular disorders. A scoping review design and methodology were used due to the exploratory nature of the research question, according to literature searches on PubMed/Medline, Scopus, Web of Science (WoS), and Physiotherapy Evidence Database (PEDro) electronic databases using the following keywords: “Anterior Cruciate Ligament”, “ACL”, “SARS-CoV-2”, and “COVID-19”. Undertraining and muscular knee imbalance might cause inefficient movement strategies, lack of knee stability, and increasing load with negative implications in ACL injuries. In the post-surgery period, during COVID-19, telerehabilitation approaches appeared to be successfully applied to maintain strength and range of motion in this condition. However, no definitive data are available regarding the most effective interventions. This scoping review showed the influence of the COVID-19 pandemic and associated restrictions on postoperative and rehabilitative care of ACL injuries.

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The challenges faced by patients with hereditary myopathy during the COVID-19 pandemic

Türken,

Çapar,

Kurt

et al. 2024

Int J Palliat Nurs

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Background: Neuromuscular diseases are inherited and the prevalance of neuromuscular disease is estimated to be around 1:2000. Methods: This cross-sectional research was conducted with a qualitative research model. Data were collected from patients with an online survey using the snowball sampling method. The study was conducted in accordance with the STROBE checklist methodology. Frequencies and percentages were used to analyse demographic data, and content analysis was used for qualitative opinions. Results: Most of the participants were men and their education levels were low. Participants reported experiencing physical and socio-economic barriers to accessing healthcare. Participants also stated that these barriers have worsened since COVID-19. Conclusions: Patients with hereditary myopathy are stigmatised by society and face different problems depending on the type of disease and level of function. It is recommended that decision-makers enable patients with hereditary myopathy in exceptional situations to access healthcare services and take steps to resolve their problems.

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A Comprehensive Review of Neuromuscular Manifestations of COVID-19 and Management of Pre-Existing Neuromuscular Disorders in Children

Cited by 4 publications

References 71 publications

Effects of the COVID-19 Pandemic on SMA Screening and Care: Physician and Community Insights

Effects of the COVID-19 Pandemic on SMA Screening and Care: Physician and Community Insights

Impact of COVID-19 Era on the Anterior Cruciate Ligament Injury Rehabilitation: A Scoping Review

The challenges faced by patients with hereditary myopathy during the COVID-19 pandemic

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