A Comprehensive Review of Hepatic Hemangioma Management

Aziz, Hassan; Brown, Zachary J.; Baghdadi, Azarakhsh; Kamel, Ihab R.; Pawlik, Timothy M.

doi:10.1007/s11605-022-05382-1

Cited by 29 publications

(27 citation statements)

References 48 publications

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“…The true incidence of MHH remains undetermined as many small lesions produce no symptoms and are impossible to identify. MHHs are sometimes incidentally detected only during imaging scans for various unrelated pathologies [5,17]. It follows then that screening should be a common practice during the first months of life for infants with the above-mentioned skin lesions [18].…”

Section: Discussionmentioning

confidence: 99%

Is the Identification of Multiple Infantile Cutaneous Hemangiomas Always a Definitive Diagnosis? A Case Report of an Infant with a Multifocal Hepatic Hemangioma (MHH)

Baranowska,

Boral,

Jarzumbek

et al. 2023

Preprint

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Multifocal hepatic hemangiomas (MHHs) are the most common benign vascular tumours of the liver that are detected in children with concomitant multiple infantile hemangiomas. They still pose a diagnostic problem for GPs and are thus often detected far too late, due to their low prevalence rates. MHHs are usually undetectable at birth, usually detected within the first few weeks of life when the lesions proliferate. The heterogeneity of the lesions and the presence of comorbidities make often the management of infantile hepatic hemangiomas a true challenge, also for highly specialised medical professionals. Ultrasound (USG) should be the imaging examination performed in the first instance in search for vascular anomalies in children. In pharmacotherapy, the first choice treatment is propranolol and prednisone, administered orally. Invasive treatment is usually indicated in symptomatic or progressive multiple hepatic hemangiomas only. Recently published studies show a significant decrease in the incidence rate of the disease, which now ranges between 11% and 18% for treated and untreated hepatic hemangiomas, respectively.

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Section: Discussionmentioning

confidence: 99%

Is the Identification of Multiple Infantile Cutaneous Hemangiomas Always a Definitive Diagnosis? A Case Report of an Infant with a Multifocal Hepatic Hemangioma (MHH)

Baranowska,

Boral,

Jarzumbek

et al. 2023

Preprint

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“…Hepatic hemangiomas are the most common benign liver lesions that are found incidentally on routine abdominal cross-sectional imaging and are usually asymptomatic and remain stable in size, subsequently requiring no treatment [ 7 , 8 , 9 ]. When patients present with large lesions (>5 cm in diameter) with a progressive increase in size and are symptomatic as related to the lesions, a specific treatment is usually needed [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Medium and Long-Term Outcome of Superselective Transcatheter Arterial Embolization with Lipiodol–Bleomycin Emulsion for Giant Hepatic Hemangiomas: Results in 241 Patients

Yuan¹,

Zhang

Duan

et al. 2022

JCM

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Purpose: To evaluate the medium and long-term efficacy of superselective transcatheter arterial embolization (TAE) with lipiodol–bleomycin emulsions (LBE) for giant hepatic hemangiomas. Methods: A total of 241 patients who had underwent TAE with LBE for hepatic hemangiomas from January 2010 to December 2016 were retrospectively reviewed. Blood tests were performed 3 and 7 days after TAE and procedural-related complications were recorded. The patients were followed up by enhanced CT or MRI imaging at 6, 12, 36, and 60 months post-TAE, respectively. Technical success of TAE was defined as successful embolization of all identifiable arteries supplying to the hemangiomas. Clinical success was defined as improvement of the abdominal symptoms and indications on the imaging examinations that the hemangiomas had decreased by more than 50% in maximum diameter. Results: TAE was performed successfully in all patients without serious complications. Improvement of the abdominal symptoms was recorded in 102/102 cases (100%). The reduction rate of the tumor maximum diameter with >50% at 6, 12, 36, and 60 months was 88.1% (190/210), 86.7% (170/196), 85.2% (124/142), and 86.5% (45/52), respectively. There was a significant change from pre-TAE to follow-up values in maximum diameter (p < 0.05). Conclusion: TAE with LBE was feasible and effective for giant hepatic hemangiomas. The reductions of the tumor maximum diameter with >50% at medium (≥3 years) and long-term (≥5 years) follow-up were satisfactory, with 85.2% and 86.5%, respectively.

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“…Other causes such as gallstones and gastroduodenal diseases should be ruled out. Studies have indicated that about 25% of patients experience persistent symptoms after liver resection (11,18). Another study also suggested that surgery for 5-10 cm asymptomatic hemangiomas should be limited (19).…”

Section: Surgical Indicationsmentioning

confidence: 99%

Surgical indications for solid hepatic benign tumors: An updated literature review

Zhang,

Ji,

Qiu

et al. 2023

BST

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Hepatic hemangioma, focal nodular hyperplasia, and hepatic adenoma are the most common benign solid liver tumors. However, their surgical indications have been the subject of debate. Minimally invasive liver resection reduces the cost of surgery and may lead to overtreatment of benign liver tumors. Recently, there has been a growing understanding of the etiology, pathogenesis, and natural history of these tumors. Great progress has also been made in imaging. The use of MRI and contrast agents has improved the accuracy of non-invasive diagnosis of these tumors, and especially in the identification of specific molecular subtypes of liver adenoma. These factors have resulted in alterations of surgical indications for these tumors. This article examines recent literature and it discusses the surgical indications for hepatic hemangioma, focal nodular hyperplasia, and hepatic adenoma while summarizing modifications in clinical management.

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A Comprehensive Review of Hepatic Hemangioma Management

Cited by 29 publications

References 48 publications

Is the Identification of Multiple Infantile Cutaneous Hemangiomas Always a Definitive Diagnosis? A Case Report of an Infant with a Multifocal Hepatic Hemangioma (MHH)

Is the Identification of Multiple Infantile Cutaneous Hemangiomas Always a Definitive Diagnosis? A Case Report of an Infant with a Multifocal Hepatic Hemangioma (MHH)

Medium and Long-Term Outcome of Superselective Transcatheter Arterial Embolization with Lipiodol–Bleomycin Emulsion for Giant Hepatic Hemangiomas: Results in 241 Patients

Surgical indications for solid hepatic benign tumors: An updated literature review

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