A comprehensive review: Botany, phytochemistry, traditional uses, pharmacology, and toxicology of Spatholobus suberectus vine stems

Huang, Xiao‐Jun; Fei, Qingqing; Yu, Shuang; Liu, Shengjin; Zhang, Li; Chen, Xialin; Cao, Lei; Wang, Zhenzhong; Shan, Mingqiu

doi:10.1016/j.jep.2023.116500

Cited by 3 publications

(1 citation statement)

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“…In traditional Chinese medicine, their pharmacological applications are vastly different, with the former primarily used as an insecticide, [ 2 ] while the latter is known to promote blood circulation. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

Uncommon Millettia pachycarpa Benth poisoning: A case report

Long,

Huang,

Guo

2024

Medicine

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Background: Millettia pachycarpa Benth, rich in rotenone, can disrupt the mitochondrial electron transport chain. Ingestion may cause respiratory and central nervous system depression, and in severe cases, lead to death. This is the first detailed clinical case report of M. pachycarpa Benth poisoning, aiming to help systematization of diagnosis and treatment. Patient concerns: An elderly male who lost consciousness for 3 hours after consuming the fruit of M. pachycarpa Benth. Arterial blood gas analysis indicated a significant decrease in pH, a sharp increase in lactate levels, and elevated CO2 partial pressure with normal O2 partial pressure. Diagnosis: The patient was diagnosed with food intoxication by M. pachycarpa Benth, concomitant with aspiration pneumonia and distributive shock. Interventions: The patient was given continuous renal replacement therapy (CRRT) and invasive mechanical ventilation. Outcomes: The patient was successfully discharged after 5 days of hospitalization. Follow-up after 2 weeks showed no significant discomfort. Conclusion: Isolated CO2 retention without hypoxemia, significantly reduced pH, and markedly elevated lactate levels strongly suggest poisoning by M. pachycarpa Benth. CRRT and invasive mechanical ventilation are beneficial for patients. Early implementation of CRRT to remove toxins and early initiation of assisted ventilation to improve respiratory failure are recommended upon suspicion of the disease.

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Section: Discussionmentioning

confidence: 99%

Uncommon Millettia pachycarpa Benth poisoning: A case report

Long,

Huang,

Guo

2024

Medicine

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Effectiveness and safety of Chinese herbal footbaths as an adjuvant therapy for dysmenorrhea: a systematic review and meta-analysis

Tian,

Wei,

Zhuang

et al. 2024

Front. Pharmacol.

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ObjectivesTo evaluate the effectiveness and safety of Chinese herbal footbaths (CHF) as an adjunctive therapy in managing dysmenorrhea.MethodsTen electronic databases were searched to identify eligible randomized clinical trials (RCTs) from inception until June 2023. Outcome measurements encompassed the total effective rate, visual analog scale (VAS) score of pain intensity, Cox menstrual symptom scale (CMSS) score, symptom score, Traditional Chinese Medicine (TCM) syndrome scale, and any reported adverse events. The methodological quality of the included studies was assessed with the Cochrane collaboration tool. Review Manager 5.3 software was employed for quantitative synthesis, and funnel plots were utilized to evaluate potential reporting bias.ResultsEighteen RCTs with 1,484 dysmenorrhea patients were included. The aggregated results suggested that the adjunctive CHF could significantly ameliorate dysmenorrhea, as evident from the improved total effective rate [risk ratio (RR) 1.18, 95% confidence interval (CI): 1.12 to 1.23, P < 0.00001], VAS (MD 0.88, 95% CI: 0.68 to 1.09, P < 0.00001), CMSS (MD 3.61, 95% CI: 2.73 to 4.49, P < 0.00001), symptom score (SMD 1.09, 95% CI: 0.64 to 1.53, P < 0.00001), and TCM syndrome scale (MD 3.76, 95% CI: 2.53 to 4.99, P < 0.0001). In addition, CHF presented fewer adverse events with a better long-term effect (RR 1.34, 95% CI: 1.11 to 1.63, P < 0.01) and diminished recurrence rate (RR 0.19, 95% CI: 0.09 to 0.39, P < 0.0001).ConclusionCurrent evidence implies that CHF may be an effective and safe adjunctive therapy for patients with dysmenorrhea. However, the methodological quality of the studies included was undesirable, necessitating further verification with more well-designed and high-quality multicenter RCTs.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=188256, identifier registration number.

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Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy

Stasiłowicz-Krzemień,

Gościniak,

Formanowicz

et al. 2024

IJMS

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Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, a cornerstone in cancer treatment, aims to destroy cancer cells while minimizing harm to healthy tissues. However, the harmful effects of irradiation on normal cells present a formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines the diverse classes of natural compounds, elucidating their roles as protectants of healthy cells. Furthermore, the review highlights the potential of these compounds as radioprotective agents capable of enhancing the body’s resilience to radiation therapy. By integrating natural radioprotectors into cancer treatment regimens, clinicians may improve therapeutic outcomes while minimizing the adverse effects on healthy tissues. Ongoing research in this area holds promise for developing complementary strategies to optimize radiotherapy efficacy and enhance patient quality of life.

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A comprehensive review: Botany, phytochemistry, traditional uses, pharmacology, and toxicology of Spatholobus suberectus vine stems

Cited by 3 publications

References 50 publications

Uncommon Millettia pachycarpa Benth poisoning: A case report

Uncommon Millettia pachycarpa Benth poisoning: A case report

Effectiveness and safety of Chinese herbal footbaths as an adjuvant therapy for dysmenorrhea: a systematic review and meta-analysis

Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy

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