A Comprehensive Public Health Conceptual Framework and Strategy to Effectively Combat Cholangiocarcinoma in Thailand

Khuntikeo, Narong; Loilome, Watcharin; Thinkhamrop, Bandit; Chamadol, Nittaya; Yongvanit, Puangrat

doi:10.1371/journal.pntd.0004293

Cited by 54 publications

(44 citation statements)

References 45 publications

(54 reference statements)

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“…Opisthorchiasis is inarguably associated with cholangiocarcinoma in Southeast Asia (Khuntikeo et al, 2016, Haswell-Elkins et al, 1994) and is classified as Group 1 carcinogen by the IARC (Bouvard et al, 2009, IARC, 2012, de Martel et al, 2012). Together with O. viverrini infection, co-factors such as environmental or exotic microbes in the biliary system that resist host inflammatory responses might also contribute to carcinogenesis (Sripa et al, 2007, Plieskatt et al, 2013, Chng et al, 2016).…”

Section: Liver Fluke Infections and Cholangiocarcinomamentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity.

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Section: Liver Fluke Infections and Cholangiocarcinomamentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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“…Infection with the fish-borne liver flukes, Opisthorchis viverrini and Clonorchis sinensis, as well as the infection with H. pylori are all classified as Group 1 carcinogens by the International Agency for Research on Cancer [6]. Opisthorchiasis is a major risk factor for cholangiocarcinoma in northeastern Thailand and Laos [6][7][8][9]. In addition to gastric disease, infection with species of Helicobacter causes hepatobiliary tract diseases that can resemble opisthorchiasis [5,8,9,11,12].…”

Section: H Pylori Induces Anchorage-independent Colony Formationmentioning

confidence: 99%

“…The International Agency for Research on Cancer of the World Health Organization classifies infection with the liver flukes O. viverrini and Clonorchis sinensis as well as H. pylori as Group 1 carcinogens [6]. In northern and northeastern Thailand and Laos, opisthorchiasis is the major documented risk factor for CCA [6][7][8][9]. Given the elevated prevalence of CCA in this region where infection with liver fluke prevails, and given evidence of linkages between infection by Helicobacter during opisthorchiasis, these two biological carcinogens together may orchestrate the pathogenesis of opisthorchiasis and bile duct cancer.…”

Section: Introductionmentioning

confidence: 99%

Infection with CagA⁺Helicobacter pylori induces epithelial to mesenchymal transition in human cholangiocytes

Thanaphongdecha

Speigh

Tanno

et al. 2020

Preprint

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Recent reports suggest that the East Asian liver fluke Opisthorchis viverrini, which is implicated in pathogenesis of opisthorchiasis-associated cholangiocarcinoma, serves as a reservoir of Helicobacter pylori. The affected cholangiocytes that line the intrahepatic biliary tract are considered to be the cell of origin of this malignancy. Here, we investigated interactions among a human cholangiocyte cell line, H69, a CCA cell line CC-LP-1, CagA+ve Helicobacter pylori, and H. bilis bacilli. Exposure to increasing numbers of H. pylori at 0, 1, 10,100 bacteria per cholangiocyte cell induced phenotypic changes in the cultured cholangiocytes including profusion of thread-like filopodia and loss of cell-cell contact in a dose-dependent fashion. In parallel, changes in mRNA expression followed exposure to H. pylori, with increased expression of epithelial to mesenchymal transition (EMT) associated-factors including snail, slug, vimentin, matrix metalloprotease, zinc finger E-box-binding homeobox, and the cancer stem cell marker CD44. Transcription levels encoding the cell adhesion marker CD24 decreased. Analysis in real time using the xCELLigence system to quantify cell proliferation, migration and invasion revealed that exposure to ten to 50 of H. pylori stimulated migration of H69 cells and CC-LP-1 cells, a line derived form of a human cholangiocarcinoma, and invasion through an extracellular matrix. In addition, ten bacilli of CagA+ve H. pylori stimulated contact-independent colony establishment in soft agar. These findings support the hypothesis that infection with H. pylori can contribute to the malignant transformation of the biliary epithelium.

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“…The results were so positive that the Lawa Model has been hailed as a flagship approach by the World Health Organization (see http://www.who.int/neglected_diseases/news/ fbti_thailand_uses_integrated_ecosystems_health_approach/en/) and has been recommended by WHO as an approach worth implementing in other areas and countries. Another approach that has also been initiated in Thailand is the Cholangiocarcinoma Screening and Care Program (CASCAP), which is primarily to instigate long-term screening of population at risk of O. viverrini infection and CCA (of whom approximately 20 million are in Thailand, where this initiative is located) such that precancerous changes to the biliary tract and liver are identified in addition to early stage CCA that can be successfully treated (Khuntikeo et al, 2016). Despite being targeted at the clinical level, CASCAP also seeks to address research needs (particularly regarding diagnostics and treatment), to address the socioeconomic aspects of CCA at the community level with the intention of developing policies to address the impact, and to review the efficacy of current control and prevention programs, including education, in order to develop measures for control of O. viverrini infections and CCA.…”

Section: Current and New Efforts Toward Research And Controlmentioning

confidence: 99%

Parasites in Food: From a Neglected Position to an Emerging Issue

Robertson

2018

Biological Emerging Risks in Foods

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Foodborne parasites have long been a neglected group of pathogens, as they often have insidious, chronic effects, rather than being acute diseases, and they are often associated with impoverished or marginalized populations. In addition, due to the long incubation period for most foodborne parasites, source attribution is often difficult, if not impossible. However, global trends have enabled foodborne parasites to emerge in different populations in new locations, transmitted through different food types, and sometimes with unexpected symptoms. This emergence of foodborne parasites has brought them into focus. In this chapter, six foodborne parasites are used as examples on emergence: Echinococcus multilocularis is spreading to new locations; Cryptosporidium spp. are beginning to be associated not only with water, but also with salads; Trypanosoma cruzi is being manifest with acute disease due to foodborne transmission, particularly transmitted with juices; Trichinella spp. have become less of a burden regarding transmission via pork in many countries, but now game animals are becoming a concern; anisakiasis is becoming a global problem as the world develops a taste for sushi, and similarly for opisthorchiasis, which is increasingly being associated with cholangiocarcinoma. However, the emergence of these foodborne parasites provides an incentive for increased efforts being made toward control. In this chapter, having described how the parasites are emerging from their neglected position, the focus turns toward control. In addition to considering control measures that may be applied to the specific parasites, an overview is provided of some of the organized collaborations, projects, and consortia, as well as some of their outputs, that have in focus the control of these emerging and important pathogens.

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A Comprehensive Public Health Conceptual Framework and Strategy to Effectively Combat Cholangiocarcinoma in Thailand

Cited by 54 publications

References 45 publications

Parasite Infection, Carcinogenesis and Human Malignancy

Parasite Infection, Carcinogenesis and Human Malignancy

Infection with CagA⁺Helicobacter pylori induces epithelial to mesenchymal transition in human cholangiocytes

Parasites in Food: From a Neglected Position to an Emerging Issue

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A Comprehensive Public Health Conceptual Framework and Strategy to Effectively Combat Cholangiocarcinoma in Thailand

Cited by 54 publications

References 45 publications

Parasite Infection, Carcinogenesis and Human Malignancy

Parasite Infection, Carcinogenesis and Human Malignancy

Infection with CagA+Helicobacter pylori induces epithelial to mesenchymal transition in human cholangiocytes

Parasites in Food: From a Neglected Position to an Emerging Issue

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Infection with CagA⁺Helicobacter pylori induces epithelial to mesenchymal transition in human cholangiocytes