A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines

Hong, Ming; Lan, Tianshu; Li, Qiuxia; Li, Binfei; Yao, Yuan; Xu, Feng; Wang, Weijia

doi:10.1080/19490976.2023.2233146

Cited by 8 publications

(5 citation statements)

References 123 publications

(157 reference statements)

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“…Gut microbiota changes during infection provide insights into disease mechanisms. Animal models could help design gut-microbiota-targeting treatments [32,11] . The gut microbiota diversity in COVID-19 patients and Type 2 diabetes patients may be influenced by antibiotic use and T2D.…”

Section: Discussionmentioning

confidence: 99%

“…The microbiota in the gut is very critical in the course of the immune response and the performance of the vaccine. Animal experiments, clinical interventional studies, as well as observational studies provide scientific evidence about interrelation between gut microbiota and COVID-19 vaccines [11,28] . Asymptomatic COVID-19 carriers, often silent or presymptomatic, pose challenges to control.…”

Section: The Reciprocal Relationships Between Gut Microbiota and Covi...mentioning

confidence: 99%

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The influence of coronaviruses on the human gut microflora

Hejran,

Sarwari,

Monib

et al. 2024

Int. J. Adv. Biochem. Res.

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The influence of coronaviruses on the human gut microflora is a topic of emerging interest within the scientific community. Coronaviruses, particularly those like SARS-CoV-2, which causes COVID-19, are primarily known for respiratory symptoms but have broader impacts on human health. Recent research suggests that coronaviruses can affect the gut microflora, the diverse community of microorganisms inhabiting the gastrointestinal tract, which plays a crucial role in human health and disease. Studies indicate that coronaviruses may disrupt the gut microflora directly or indirectly. Direct effects could occur through viral invasion of intestinal cells expressing the ACE2 receptor, which is the cellular entry point for coronaviruses. Indirect effects may arise due to systemic inflammation triggered by the viral infection, affecting gut microbial composition and function. Dysbiosis, an imbalance in gut microbial communities, has been observed in COVID-19 patients, indicating potential coronavirusmediated alterations. Understanding these interactions is vital because the gut microflora influences immune responses, nutrient metabolism, and overall well-being. Altered microbial profiles due to coronavirus infections might contribute to the prolonged gastrointestinal symptoms reported in COVID-19 patients. Moreover, changes in gut microflora composition could impact the efficacy of therapies and vaccines, given the role of the microflora in modulating immune system function. Future research should explore the mechanisms underlying coronavirus-mediated alterations in gut microflora and their implications for health outcomes. This includes investigating how viral infections influence specific microbial species and their metabolic activities. Longitudinal studies are needed to assess whether these changes persist beyond the acute phase of infection and how they correlate with clinical outcomes. In summary, coronaviruses can exert significant influences on the human gut microflora, potentially disrupting microbial communities and functions essential for health. This understanding could inform therapeutic strategies targeting gut microflora to improve outcomes in coronavirusinfected individuals and enhance our broader understanding of host-microflora interactions in infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Section: The Reciprocal Relationships Between Gut Microbiota and Covi...mentioning

confidence: 99%

The influence of coronaviruses on the human gut microflora

Hejran,

Sarwari,

Monib

et al. 2024

Int. J. Adv. Biochem. Res.

View full text Add to dashboard Cite

show abstract

“…Preliminary evidence suggests that the administration of probiotics and prebiotics may be effective in reestablishing gut microbiota and lowering the probability of secondary infections caused by bacterial translocation Kullar et al, 2021). Furthermore, recent studies indicate that a healthy gut microbiota not only reduces the severity of COVID-19 but may also positively influence the efficacy of vaccines (Hong et al, 2023;Ng et al, 2023). As part of a One Health approach, successful mitigation of SARS-CoV-2 will only be possible by controlling transmission in susceptible species.…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 in a common woolly monkey (Lagothrix lagothricha): First evidence of fatal outcome in a nonhuman primate after natural SARS‐CoV‐2 infection

Diaz,

Sáenz,

Cabrera

et al. 2024

American J Primatol

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Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), was declared a pandemic by the World Health Organization in March 2020. Since then, viral spread from humans to animals has occurred worldwide. Nonhuman primates (NHPs) have been found to be susceptible to reverse‐zoonosis transmission of SARS‐CoV‐2, but initial research suggested that platyrrhine primates are less susceptible than catarrhine primates. Here we report the natural SARS‐CoV‐2 infection of a common woolly monkey (Lagothrix lagothricha) from a wildlife rehabilitation center in Ecuador. The course of the disease, the eventual death of the specimen, and the pathological findings are described. Our results show the susceptibility of a new platyrrhine species to SARS‐CoV‐2 and provide evidence for the first time of a COVID‐19‐associated death in a naturally infected NHP. The putative route of transmission from humans, and implications for captive NHPs management, are also discussed. Given that common woolly monkeys are at risk of extinction in Ecuador, further understanding of the potential threat of SARS‐CoV‐2 to their health should be a conservation priority. A One Health approach is the best way to protect NHPs from a new virus in the same way that we would protect the human population.

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“…It appears that different microbiome components either enhance or reduce the efficacy of COVID‐19 vaccines, indicating a bidirectional relationship between the gut microbiome and the vaccine. 132 The human gut microbiota and its metabolites may be involved in vaccine response. Vaccination is accompanied by changes in the composition and functional pathways of the gut microbiota, and the gut microbiota and its functional spectrum are related to the vaccine response.…”

Section: Dynamic Changes Of Microbiota In Covid‐19mentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines

Cited by 8 publications

References 123 publications

The influence of coronaviruses on the human gut microflora

The influence of coronaviruses on the human gut microflora

COVID‐19 in a common woolly monkey (Lagothrix lagothricha): First evidence of fatal outcome in a nonhuman primate after natural SARS‐CoV‐2 infection

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

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