A comprehensive overview of exosome lncRNAs: emerging biomarkers and potential therapeutics in endometriosis

Abstract

Endometriosis is a gynecological condition that significantly impacting women’s daily lives. In recent years, the incidence of endometriosis has been rising yearly and is now an essential contributor to female infertility. Exosomes are extracellular vesicles (EVs) that carry long noncoding RNA (lncRNA) and shield lncRNA from the outside environment thanks to their vesicle-like structure. The role of exosome-derived lncRNAs in endometriosis is also receiving more study as high-throughput sequencing technology develops. Several lncRNAs with variable expression may be crucial to the emergence and growth of endometriosis. The early diagnosis of endometriosis will be considerably improved by further high specificity and sensitivity Exosome lncRNA screening. Exosomes assist lncRNAs in carrying out their roles, offering a new target for creating endometriosis-specific medications. In order to serve as a reference for clinical research on the pathogenesis, diagnosis, and treatment options of endometriosis, this paper covers the role of exosome lncRNAs in endometriosis and related molecular mechanisms.

Extracellular vesicles in endometriosis: role and potential

“…They play a regulatory role in gene expression through interactions with miRNAs, mRNAs, or proteins. Recent studies have shown that lncRNAs are essential for maintaining intracellular homeostasis and play a crucial role in the development of EMs (42)(43)(44). lncRNA HOTAIR has been reported to be associated with the progression of several diseases (45,46).…”