A comprehensive multiplatform metabolomic analysis reveals alterations of 2-hydroxybutyric acid among women with deep endometriosis related to the pesticide trans-nonachlor

Lefebvre, Tiphaine; Campas, Manon; Matta, Komodo; Ouzia, Sadia; Guitton, Yann; Duval, Gauthier; Ploteau, Stéphane; Marchand, Philippe; Le Bizec, Bruno; Freour, Thomas; Antignac, Jean-Philippe; de Tullio, Pascal; Cano-Sancho, German

doi:10.1016/j.scitotenv.2024.170678

Cited by 1 publication

(1 citation statement)

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“…also found that short-chain fatty acids were reduced in the feces of mice with endometriosis, and treatment with n-butyrate reduced the growth of endometriosis lesions in mice ( Chadchan et al., 2021 ). A case-control study of 137 women found that the serum metabolite 2-hydroxybutyric acid was associated with endometriosis risk ( Lefebvre et al., 2024 ). These studies have proved that SCFAs can affect the occurrence and development of EMS.…”

Section: Gut Microbiota Metabolites: Scfasmentioning

confidence: 99%

Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis

Liu,

Peng,

Tian

et al. 2024

Front. Cell. Infect. Microbiol.

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In recent years, a growing body of research has confirmed that the gut microbiota plays a major role in the maintenance of human health and disease. A gut microbiota imbalance can lead to the development of many diseases, such as pregnancy complications, adverse pregnancy outcomes, polycystic ovary syndrome, endometriosis, and cancer. Short-chain fatty acids are metabolites of specific intestinal bacteria and are crucial for maintaining intestinal homeostasis and regulating metabolism and immunity. Endometriosis is the result of cell proliferation, escape from immune surveillance, and invasive metastasis. There is a strong correlation between the anti-proliferative and anti-inflammatory effects of short-chain fatty acids produced by gut microbes and the development of endometriosis. Given that the mechanism of action of gut microbiota and Short-chain fatty acids in endometriosis remain unclear, this paper aims to provide a comprehensive review of the complex interactions between intestinal flora, short-chain fatty acids and endometriosis. In addition, we explored potential microbial-based treatment strategies for endometriosis, providing new insights into the future development of diagnostic tests and prevention and treatment methods for endometriosis.

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Section: Gut Microbiota Metabolites: Scfasmentioning

confidence: 99%