A Comprehensive Look at Irritable Bowel Syndrome and its Associated Factors Considering the Rome IV Criteria: A Penalized Smoothly Clipped Absolute Deviation Regression Approach in the Pars Cohort Study

Abstract

BACKGROUND After the introduction of the Rome IV criteria for the diagnosis of irritable bowel syndrome (IBS), studies on the clinical significance of the new criteria in the settings of a large study has been scarce. Objective: Herein we used the infrastructures provided by one the largest cohort studies in Iran to evaluate the epidemiological features related to IBS. METHODS A total of 9264 participants, were enrolled in the initial registry. Diagnosis of IBS was done using the Rome IV criteria. Individuals with IBS were compared with a control group. Since the study included a large sample size of patients, we used the penalized smoothly clipped absolute deviation (SCAD) regression analysis to construct a model for the evaluation of factors associated with IBS. RESULTS Overall, data of 9163 participants entered the final analysis. In total, 1067 (11.6%) individuals were diagnosed with IBS, among which 57 (5.3%) were diarrhea dominant (IBS-D), 380 (35.6%) were constipation dominant (IBS-C), and 630 (59%) did not mention having any of the two (IBS-U). In the regression model, back pain/arthralgia (OR: 1.98, 95% CI: 1.65 - 2.40), insomnia (OR: 1.65, 95% CI: 1.40 - 1.93), depression (OR: 1.64, 95% CI: 1.38 - 1.95), female sex (OR: 1.58, 95% CI: 1.27 - 1.96), anxiety (OR: 1.43, 95% CI: 1.21 - 1.69), and being married (OR: 1.23, 95% CI: 1.03 - 1.48), were associated with higher rates of IBS. We found that IBS prevalence displays a peak at the age of 41 years for both men and women. CONCLUSION The present study provides a background for follow-up studies to be conducted in order to evaluate causality between IBS and some major diseases such as liver disease. We also found that opium use, although not statistically significant, in addition to sex, education, back/joint pain, depression, insomnia, anxiety, and marital status might be a contributing factor in IBS.

The prevalence of irritable bowel syndrome among Saudi population in Riyadh by use of Rome IV criteria and self-reported dietary restriction

“…The prevalence of IBS was numerically higher in the unmarried population than in their married counterparts. This finding is consistent with the results of other studies,[ 1 38 39 40 ] although our findings did not reach statistical significance.…”

“…According to some studies,[ 38 40 ] IBS has an inverse relationship with education. Contrary to this, we observed the opposite and our results found the educational level to be an important contributor for IBS.…”

The irritable bowel syndrome prevalence of amidst Iraqi inhabitance in Kirkuk via utilizing of Rome IV gauge

“…IBS was found to be more common in unmarried people than in their married counterparts. Despite the fact that our results did not have statistical significance, they are consistent with those of other treatises [1,38,39,40]. IBS has a converse relevance with instruction, according to several treatises [38,40] (education).…”

Health anxiety in medical employees: A multicentre study

“…25 In contrast (and consistent with our findings), one study found that being married is a risk factor in patients with irritable bowel syndrome. 26 We suggest that in the present study, the effect of marital status was confounded by age: single employees were young and had few life burdens.…”