A Comprehensive Investigation of Glycoprotein-based Nucleic Acid Vaccines for Hantaan Virus
kun yang,
Jiaxing zhang,
Junqi Zhang
et al.
Abstract:Hemorrhagic fever with renal syndrome (HFRS) occurs throughout Eurasia with considerable morbidity and mortality. Currently, the absence of specific treatments or effective antiviral drugs for hantavirus infection makes developing safe and effective vaccines a high priority. Here, we report the development of three novel nucleic acid vaccine candidates, mRNA, DNA, and DNA encapsulated in lipid nanoparticles, encoding the glycoproteins of the Hantaan virus (HTNV). To comprehensively evaluate the potential of ca… Show more
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