A comprehensive intervention for adverse drug reactions identification and reporting in a Pediatric Emergency Department

Ríos, Olga Morales; Gutiérrez, Luis Jasso; Talavera, Juan O.; Téllez-Rojo, Martha M.; López, Víctor Olivar; Garduño-Espinosa, Juan; Hernández, Onofre Muñoz

doi:10.1007/s11096-015-0209-x

Cited by 18 publications

(10 citation statements)

References 34 publications

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“…ADRs estimated frequency in the present study ranges from 2.12% to 8.07%, which is consistent with that reported in the literature [14,15,35]; however, these figures should be interpreted with caution, since: a) although doctors identify ADRs, they do not report them [37], which causes an underreporting of 93.9% [38] and, therefore, the magnitude of the problem is underestimated, and b) the methodologies used in the studies are different, which makes comparison between them difficult. On the other hand, variations in ADR frequency could be attributed to factors such as: a) under-reporting [38], since ADRs notification at HIMFG is voluntary; b) the CIF temporarily assigned pharmacy students to hospitalization areas in order for them to take care of reporting the ADRs experienced by patients, given that, at HIMFG, there are no clinical pharmacists who, among other things, are qualified to report ADRs; and c) one of the authors of this study (CCO) implemented, among the activities of the hematological oncology department residents, the report of ADRs experienced by patients diagnosed with any neoplastic disease.…”

Section: Discussionsupporting

confidence: 91%

“…The frequency of drug-related deaths identified in this study is 1.1%, which is consistent with that reported in the literature (0.1% to 13%) [32]; however, it is important to consider that there is wide variability in published values and that, as previously mentioned, ADR underreporting at HIMFG is 93.9% [38] and, thus, the problem might be underestimated. Antineoplastic and immunomodulating agents use and febrile neutropenia occurred more commonly in patients whose outcome was drug-related death, which has already been widely studied in patients on cancer treatment [49,50].…”

Section: Plos Onesupporting

confidence: 91%

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Descriptive study of adverse drug reactions in a tertiary care pediatric hospital in México from 2014 to 2017

et al. 2020

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Introduction In Pediatrics, adverse drug reactions (ADRs) affect morbidity and mortality. In Mexico, the characteristics of ADRs and suspect drugs have not been described in hospitalized children. Objective To estimate the frequency of ADRs and describe them, as well as suspect drugs, in a tertiary care pediatric hospital in Mexico. Methods A total of 1,649 Hospital Infantil de Mexico Federico Gó mez ADR reports were analyzed. Completeness of the information was assessed, and ADRs severity and seriousness were assigned based on NOM-220-SSA1-2012, with causality being established according to the Naranjo algorithm. ADRs were classified with WHO Adverse Drug Reaction Terminology (WHO-ART). The drugs involved in ADRs were categorized according to the Anatomical Therapeutic Chemical (ATC) classification. Descriptive analysis was performed using the SPSS 20 statistical package. Results Of all the reports, 5.8% lacked sufficient information for the analysis (grade 0). ADRs frequency ranged from 2.12% to 8.07%. ADRs occurred most commonly in children (56.9%),

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Section: Discussionsupporting

confidence: 91%

Section: Plos Onesupporting

confidence: 91%

Descriptive study of adverse drug reactions in a tertiary care pediatric hospital in México from 2014 to 2017

et al. 2020

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“…The present study is a secondary data analysis from a comprehensive intervention for adverse drug reactions identification and reporting in a pediatric ED [ 21 ]. The period of study was from March 2012 to June 2013.…”

Section: Methodsmentioning

confidence: 99%

“…During the intervention study [ 21 ], one of the authors of this work (OMR) collected the information from the medical record of each patient who was admitted to the ED. The collected data included: age, gender, weight, height, diagnoses, date of admission and discharge, presence of adverse drug reactions (ADRs), and medications received during the ED stay (drug name, dose, administration route and date).…”

Section: Methodsmentioning

confidence: 99%

Potential drug-drug interactions and their risk factors in pediatric patients admitted to the emergency department of a tertiary care hospital in Mexico

et al. 2018

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BackgroundDrug-drug interactions (DDIs) detected in a patient may not be clinically apparent (potential DDIs), and when they occur, they produce adverse drug reactions (ADRs), toxicity or loss of treatment efficacy. In pediatrics, there are only few publications assessing potential DDIs and their risk factors. There are no studies in children admitted to emergency departments (ED). The present study estimates the prevalence and describes the characteristics of potential DDIs in patients admitted to an ED from a tertiary care hospital in Mexico; in addition, potential DDI-associated risk factors are investigated.MethodsA secondary analysis of data from 915 patients admitted to the ED of the Hospital Infantil de México “Federico Gómez” was conducted. The Medscape Drug Interaction Checker software was used to identify potential DDIs. The results are expressed as number of cases (%), means (95% CI) and medians (25-75th percentiles). Count data regressions for number of total and severity-stratified potential DDIs were performed adjusting for patient characteristics, number of administered drugs, days of stay, presence of ADRs and diagnoses.ResultsThe prevalence of potential DDIs was 61%, with a median of 4 (2–8). A proportion of 0.2% of potential DDIs was “Contraindicated”, 7.5% were classified as “Serious”, 62.8% as “Significant” and 29.5% as “Minor”. Female gender, age, days of stay, number of administered drugs and diagnoses of Neoplasms (C00-D48), Congenital malformations (Q00-Q99), Diseases of the Blood, Blood-forming Organs and Immunity (D50-D89) and Diseases of the nervous system (G00-G99) were significantly associated with potential DDIs.ConclusionThe prevalence of potential DDIs in the ED is high, and strategies should therefore be established to monitor patients’ safety during their stay, in addition to conducting investigations to estimate the real harm potential DDIs inflict on patients.

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“…Several studies investigated attitudes towards ADR reporting and the ADR reporting practice of health care professionals [12, 13]. Namely, positive attitudes about ADR reporting were observed, but reporting practice was poor [14].…”

Section: Introductionmentioning

confidence: 99%

Analysis of spontaneous reporting of suspected adverse drug reactions for non-analgesic over-the-counter drugs from 2008 to 2017

Bukic

Rušić

Mas

et al. 2019

BMC Pharmacol Toxicol

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Background Adverse drug reaction (ADR) reporting practices by health care professionals remain poor. Over-the-counter (OTC) drugs are perceived as safe; however, they can also cause ADRs. The objective of this study was to analyze ADR reporting for OTC drugs in a 10-year period, in order to evaluate frequency of ADRs, population that ADRs most affect and reporters of ADRs of OTC drugs in Croatia. Methods Spontaneously reported ADRs of non-analgesic OTC drugs, collected from January 2008 to December 2017 were analyzed. Data was obtained from Agency for Medicinal Products and Medical Devices of Croatia (HALMED). Results There were 547 ADRs of OTC drugs reported in total and an increase in number of reports through the years was observed. Pharmacists reported 45.4% of all ADRs, and were most frequent reporters (p < 0.001). In 2017 majority of reports, 62 (49.2%), were obtained from consumers. ADRs were most frequently observed in patients aged 70 years and older (15% of ADRs). Five percent of all reports were accidental exposures among children. Conclusions Pharmacists most frequently reported ADRs of OTC drugs and consumers’ awareness of ADR reporting has risen. Other health care professionals (e.g., nurses and dentists) must be offered proper education in order to improve reporting practice of ADRs. Health care professionals should address concerns about OTC drug safety in elderly and children.

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A comprehensive intervention for adverse drug reactions identification and reporting in a Pediatric Emergency Department

Abstract: Physicians do identify ADRs, but fail to report them. The intervention increased ADR correct identification and reporting. The effect was maintained after the intervention.

Cited by 18 publications

References 34 publications

Descriptive study of adverse drug reactions in a tertiary care pediatric hospital in México from 2014 to 2017

Descriptive study of adverse drug reactions in a tertiary care pediatric hospital in México from 2014 to 2017

Potential drug-drug interactions and their risk factors in pediatric patients admitted to the emergency department of a tertiary care hospital in Mexico

Analysis of spontaneous reporting of suspected adverse drug reactions for non-analgesic over-the-counter drugs from 2008 to 2017

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